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安全信息

PHR1335

Supelco

盐酸拉贝洛尔

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

拉贝洛尔 盐酸盐

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About This Item

经验公式（希尔记法）:
C19H24N2O3 · HCl
CAS号:
32780-64-6
分子量:
364.87
EC 号:
251-211-1
MDL编号:
MFCD00057663
UNSPSC代码:
41116107
PubChem化学物质编号:
329823320
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP L0050000
traceable to USP 1356654

API类

labetalol

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

Cl.CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(N)=O

InChI

1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H

InChI key

WQVZLXWQESQGIF-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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相关类别

一般描述

Labetalol Hydrochloride is an adrenergic α-receptor and β-receptor blocking agent, widely used in the treatment of hypertension. It is a sensitive drug and is used quantitatively especially in myocardial infarction and unstable angina, since it decreases blood pressure more rapidly than other beta blockers.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Labetalol Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA1069 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361f

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Determination of labetalol hydrochloride in drug formulations by spectrophotometry
Rahman N, et al.
J. Chin. Chem. Soc., 54(1), 185-196 (2007)
Determination of labetalol hydrochloride by kinetic spectrophotometry using potassium permanganate as oxidant
Rahman N, et al.
Journal of the Mexican Chemical Society, 55(2), 105-112 (2011)
Chitra Saran et al.
The Journal of pharmacology and experimental therapeutics (2021-11-20)
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and a major concern in drug development. Altered bile acid homeostasis via inhibition of the bile salt export pump (BSEP) is one mechanism of DILI. Dasatinib, pazopanib and

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