PHR1323
L-胱氨酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
L -胱氨酸, (R,R)-3,3′-亚二硫基二(2-丙氨酸)
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关于此项目
线性分子式:
[-SCH2CH(NH2)CO2H]2
化学文摘社编号:
分子量:
240.30
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-296-3
Beilstein/REAXYS Number:
1728094
MDL number:
产品名称
L-胱氨酸, Pharmaceutical Secondary Standard; Certified Reference Material
SMILES string
N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O
InChI key
LEVWYRKDKASIDU-IMJSIDKUSA-N
InChI
1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. C3300000
traceable to USP 1161586
API family
cystine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
>240 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Application
L-半胱氨酸可用作药物标准品，用于通过色谱法测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
General description
L-半胱氨酸是一种含硫的蛋白质非必需氨基酸，可用于许多生物学应用。
用于质量控制的药物二级标准品为制药实验室和制造商提供了一种方便且高性价比的替代方法，可替代内部工作标准品的制备。
用于质量控制的药物二级标准品为制药实验室和制造商提供了一种方便且高性价比的替代方法，可替代内部工作标准品的制备。
Other Notes
要查看此材料的检验报告示例，请在下面的“文档”框中输入LRAC3784。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Simultaneous identification and determination of total content of aminoacids in food supplements-tablets by gas chromatography
Obreshkova DP, et al.
Asian journal of experimental biological sciences, 5, 57-68 (2012)
l-Cysteine
Nonvitamin and Nonmineral Nutritional Supplements, 59(11), 53-58 (2019)
Determination of cysteine in pharmaceuticals via liquid chromatography with postcolumn derivatization
Jenke DR and Brown DS
Analytical Chemistry, 59(11), 1509-1512 (1987)
Quantitative analysis of N-acetylcysteine and its pharmacopeial impurities in a pharmaceutical formulation by liquid chromatography-UV detection-mass spectrometry.
Toussaint B,
Journal of Chromatography A, 896(1-2), 191-199 (2000)
Martijn J Wilmer et al.
American journal of physiology. Renal physiology, 299(5), F905-F916 (2010-09-10)
Renal proximal tubules are highly sensitive to ischemic and toxic insults and are affected in diverse genetic disorders, of which nephropathic cystinosis is the most common. The disease is caused by mutations in the CTNS gene, encoding the lysosomal cystine
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