PHR1313
间二甲苯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
1,3-二甲苯
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线性分子式:
C6H4(CH3)2
化学文摘社编号:
分子量:
106.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-576-3
Beilstein/REAXYS Number:
605441
MDL number:
InChI
1S/C8H10/c1-7-4-3-5-8(2)6-7/h3-6H,1-2H3
SMILES string
Cc1cccc(C)c1
InChI key
IVSZLXZYQVIEFR-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to NIST 3004, traceable to USP 1601849
vapor density
3.7 (vs air)
CofA
current certificate can be downloaded
autoignition temp.
982 °F
expl. lim.
7 %
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
Quality Level
refractive index
n20/D 1.497 (lit.)
bp
138-139 °C (lit.)
mp
−48 °C (lit.)
density
0.868 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. m-Xylene is widely used as a residual solvent (RS) or organic volatile impurity (OVI) in pharmaceutical formulations.
Application
m-Xylene may be used as a pharmaceutical reference standard for the determination of the analyte in tablet formulations by chromatography. It can also be used as a residual solvent standard for the quantification of the analyte in tablet formulations by headspace gas chromatography (HS-GC) with flame ionization detection (FID) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3625 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
80.6 °F - closed cup
flash_point_c
27 °C - closed cup
法规信息
危险化学品
此项目有
Determination of Organic Volatile Impurities in Twenty-Three Different Coated Tablet Formulations Using Headspace Gas Chromatography with Flame Ionization Detection Technique
Latif A, et al.
Pharmaceutica Analytica Acta, 8, 553-553 (2017)
m-Xylene
USP43-NF38
United States Pharmacopeia/National Formulary, 6218-6218 (2013)
Rafael Silva-Rocha et al.
Environmental microbiology, 13(9), 2389-2402 (2011-03-18)
The regulatory and metabolic networks that rule biodegradation of pollutants by environmental bacteria are wired to the rest of the cellular physiology through both transcriptional factors and intermediary signal molecules. In this review, we examine some formalisms for describing catalytic/regulatory
Fei Yu et al.
Journal of hazardous materials, 192(3), 1370-1379 (2011-08-13)
The purified and oxidized multi-walled carbon nanotubes (MWCNTs) with different oxygen contents are employed as adsorbents to study their physicochemical properties and adsorption behaviors of toluene, ethylbenzene and m-xylene (TEX) in aqueous solutions. The results demonstrate that adsorption capacity is
Bethany Warren et al.
Environmental science & technology, 42(15), 5461-5466 (2008-08-30)
A series of m-xylene/NO(x) photooxidation experiments were conducted to determine the influence of light intensity and radiation spectrum on secondary organic aerosol (SOA) formation within the UC Riverside/CE-CERT environmental chamber. The environmental chamber is equipped with 80 115-W black lights
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