PHR1313
间二甲苯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
1,3-二甲苯
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线性分子式:
C6H4(CH3)2
化学文摘社编号:
分子量:
106.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-576-3
Beilstein/REAXYS Number:
605441
MDL number:
InChI
1S/C8H10/c1-7-4-3-5-8(2)6-7/h3-6H,1-2H3
SMILES string
Cc1cccc(C)c1
InChI key
IVSZLXZYQVIEFR-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to NIST 3004, traceable to USP 1601849
vapor density
3.7 (vs air)
CofA
current certificate can be downloaded
autoignition temp.
982 °F
expl. lim.
7 %
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
Quality Level
bp
138-139 °C (lit.)
mp
−48 °C (lit.)
density
0.868 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. m-Xylene is widely used as a residual solvent (RS) or organic volatile impurity (OVI) in pharmaceutical formulations.
Application
m-Xylene may be used as a pharmaceutical reference standard for the determination of the analyte in tablet formulations by chromatography. It can also be used as a residual solvent standard for the quantification of the analyte in tablet formulations by headspace gas chromatography (HS-GC) with flame ionization detection (FID) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3625 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
80.6 °F - closed cup
flash_point_c
27 °C - closed cup
法规信息
危险化学品
此项目有
Determination of Organic Volatile Impurities in Twenty-Three Different Coated Tablet Formulations Using Headspace Gas Chromatography with Flame Ionization Detection Technique
Latif A, et al.
Pharmaceutica Analytica Acta, 8, 553-553 (2017)
m-Xylene
USP43-NF38
United States Pharmacopeia/National Formulary, 6218-6218 (2013)
Sulak Sumitsawan et al.
Environmental science & technology, 45(16), 6970-6977 (2011-07-19)
Titanium dioxide (TiO(2)) is a preferred catalyst for photocatalytic oxidation of many air pollutants. In an effort to enhance its photocatalytic activity, TiO(2) was modified by pulsed plasma treatment. In this work, TiO(2) nanoparticles, coated on a glass plate, were
Dragana Bozinovski et al.
FEMS microbiology ecology, 81(1), 134-144 (2012-03-01)
A sulfate-reducing consortium maintained for several years in the laboratory with m-xylene as sole source of carbon and energy was characterized by terminal restriction fragment length polymorphism (T-RFLP) fingerprinting of PCR-amplified 16S rRNA genes and stable isotope probing of proteins
Riccardo Salvio et al.
The Journal of organic chemistry, 76(13), 5438-5443 (2011-05-27)
Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation
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