PHR1310
苯
Pharmaceutical Secondary Standard; Certified Reference Material
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关于此项目
经验公式（希尔记法）:
C6H6
化学文摘社编号:
分子量:
78.11
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-753-7
Beilstein/REAXYS Number:
969212
MDL number:
产品名称
苯, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
UHOVQNZJYSORNB-UHFFFAOYSA-N
InChI
1S/C6H6/c1-2-4-6-5-3-1/h1-6H
SMILES string
c1ccccc1
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to NIST 3000
traceable to USP 1601146
vapor density
2.77 (vs air)
vapor pressure
166 mmHg ( 37.7 °C)
74.6 mmHg ( 20 °C)
CofA
current certificate can be downloaded
autoignition temp.
1043 °F
expl. lim.
8 %
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.501 (lit.)
bp
80 °C (lit.)
mp
5.5 °C (lit.)
density
0.874 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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General description
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
Application
苯可用作药物参考标准品，用于通过各种色谱技术测定药物制剂中的苯残留。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
Other Notes
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
想要查看本品的分析证书示例，请在下框中输入LRAC3166。这只是一个示例证书，可能与您收到的批次不符。
本认证参考材料是根据国际标准化组织ISO 17034 和国际标准化组织/国际电工委员会 ISO/IEC 17025 生产和认证的。所有关于客户关系管理的信息都可以在分析证书上找到。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
signalword
Danger
Hazard Classifications
Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 1A - Eye Irrit. 2 - Flam. Liq. 2 - Muta. 1B - Skin Irrit. 2 - STOT RE 1
target_organs
Blood
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
12.2 °F
flash_point_c
-11 °C
法规信息
危险化学品
此项目有
A general static-headspace gas chromatographic method for determination of residual benzene in oral liquid pharmaceutical products.
Liu H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 54(2), 417-421 (2011)
Factors that influence the determination of residual solvents in pharmaceuticals by automated static headspace sampling coupled to capillary GC-MS.
Mulligan KJ and McCauley H
Journal of Chromatographic Science, 33(1), 49-54 (1995)
Matrix media selection for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
Urakami K, et al.
Journal of Chromatography A, 1057(1-2), 203-210 (2004)
Cliona M McHale et al.
Carcinogenesis, 33(2), 240-252 (2011-12-15)
Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated
Jelle Vlaanderen et al.
Environmental health perspectives, 119(2), 159-167 (2010-10-01)
The use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power. We performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin
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