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Merck
CN

PHR1302

Supelco

盐酸普莫卡因

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

普莫卡因 盐酸盐

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About This Item

经验公式(希尔记法):
C17H27NO3 · HCl
CAS号:
分子量:
329.86
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1554002

API类

pramoxine

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

Cl.CCCCOc1ccc(OCCCN2CCOCC2)cc1

InChI

1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChI key

SYCBXBCPLUFJID-UHFFFAOYSA-N

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一般描述

Pramoxine hydrochloride is a hydrochloride salt of pramoxine, widely used for its local anesthetic and antipruritic properties. Its ability to relieve itching arises from its stabilizing effect on the neuronal membranes of the nerve terminals. It is widely used as a pain medicine for various conditions such as skin irritations, rashes, hemorrhoids, and minor wound care.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Pramoxine hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

用于皮肤或粘膜的局部麻醉

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA1519 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Exclamation mark

警示用语:

Warning

预防措施声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study
Kircik LH
The Journal of Clinical and Aesthetic Dermatology, 4(2), 48-48 (2011)
Simultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC
Tavlarakis P,et al
Analytical Methods : Advancing Methods and Applications, 2(6), 722-727 (2010)
Comparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities
Ibrahim F, et al.
Journal of food and drug analysis, 26(3), 1160-1170 (2018)
Gary Grove et al.
Cutis, 73(2), 135-139 (2004-03-19)
An open-label, single-center, observer-blinded, controlled trial was conducted during the winter months to evaluate the moisturizing and antipruritic effects of a unique formulation of lactic acid 12% neutralized with ammonium hydroxide and pramoxine hydrochloride (HCl) 1% in 24 women with

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