PHR1301
2-苯基苯并咪唑-5-磺酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
2-苯基-5-苯并咪唑磺酸, 苯基苯并咪唑磺酸
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经验公式（希尔记法）:
C13H10N2O3S
化学文摘社编号:
分子量:
274.30
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
2-苯基苯并咪唑-5-磺酸, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
UVCJGUGAGLDPAA-UHFFFAOYSA-N
SMILES string
OS(=O)(=O)c1ccc2[nH]c(nc2c1)-c3ccccc3
InChI
1S/C13H10N2O3S/c16-19(17,18)10-6-7-11-12(8-10)15-13(14-11)9-4-2-1-3-5-9/h1-8H,(H,14,15)(H,16,17,18)
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1530809
API family
ensulizole
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
>300 °C (lit.)
application(s)
environmental
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
Ensulizole(2-Phenylbenzimidazole 5-sulfonic acid) may be used as a pharmaceutical reference standard for the determination of the analyte in sunscreen formulations by high performance liquid chromatography (HPLC) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0273 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
J Shokri et al.
Drug research, 63(11), 591-596 (2013-07-12)
There is a serious concern about the topical and systemic absorption of organic ultraviolet filters in sunscreen formulations and subsequent phototoxic and photo allergic reactions. Ideally, a sunscreen should localize in the surface of stratum corneum and create a barrier
Ashley R Heurung et al.
Dermatitis : contact, atopic, occupational, drug, 25(6), 289-326 (2014-11-11)
Sunscreen is a key component in the preventive measures recommended by dermatologists and public health campaigns aimed at reducing sunburn, early skin aging, and skin cancer. To maximize compliance, adverse reactions to sunscreens should be minimized. Although inactive ingredients cause
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