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Merck
CN
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安全信息

PHR1283

Supelco

头孢克洛

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
Cefaclor monohydrate
经验公式(希尔记法):
C15H14ClN3O4S · H2O
CAS号:
分子量:
385.82
EC 号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to BP 792
traceable to Ph. Eur. C0630000
traceable to USP 1096906

API类

cefaclor

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/m1./s1

InChI key

WKJGTOYAEQDNIA-IOOZKYRYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cefaclor belongs to the class of second generation semi-synthetic cephalosporin antibiotic drugs that is normally administered orally. With its broad-spectrum antibacterial action, cefaclor is effective against several gram-positive as well as gram-negative bacteria.

应用

Cefaclor may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3323 in the slot below. This is an example certificate only and may not be the lot that you receive.

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Simultaneous determination of cefpirome, cefaclor, ceftazidime, and cephradine in pharmaceutical formulations by reversed phase HPLC
Nawaz M, et al.
Acta Chromatographica , 23(2), 205-213 (2011)
The use of a monolithic column to improve the simultaneous determination of four cephalosporin antibiotics in pharmaceuticals and body fluids by HPLC after solid phase extraction-a comparison with a conventional reversed-phase silica-based column
Samanidou VF, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 809(1), 175-182 (2004)
Determination of cefaclor in human plasma by a sensitive and specific liquid chromatographic-tandem mass spectrometric method
Chen X, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 784(1), 17-24 (2003)
Determination of process-related impurities and degradation products in cefaclor by high-performance liquid chromatography
Lorenz LJ, et al.
Journal of Chromatographic Science, 30(6), 211-216 (1992)
Rapid and sensitive high-performance liquid chromatographic determination of four cephalosporin antibiotics in pharmaceuticals and body fluids
Samanidou VF, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 788(1), 147-158 (2003)

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