PHR1270
富马酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
富马酸
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关于此项目
线性分子式:
HOOCCH=CHCOOH
化学文摘社编号:
分子量:
116.07
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-743-0
Beilstein/REAXYS Number:
605763
MDL number:
InChI key
VZCYOOQTPOCHFL-OWOJBTEDSA-N
InChI
1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
SMILES string
OC(=O)\C=C\C(O)=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. F0600000, traceable to USP 1286708
vapor pressure
1.7 mmHg ( 165 °C)
API family
fumaric acid
CofA
current certificate can be downloaded
autoignition temp.
1364 °F
expl. lim.
40 %
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
298-300 °C (subl.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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General description
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
Application
富马酸可作为药物参考标准品，通过分光光度法对药物制剂中的分析物进行测定。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
要查看该材料的分析证书示例，请在下面的栏位中输入 LRAC1693。这只是一个示例证书，可能不是您收到的批次。
该认证参考物质（CRM）根据ISO 17034和ISO/IEC 17025进行生产和认证。所有关于该 CRM 的信息都可以在分析证书上找到。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
wgk
WGK 1
存储类别
11 - Combustible Solids
flash_point_f
523.4 °F
flash_point_c
273 °C
Spectrophotometric estimation of ketotifen fumarate in pharmaceutical formulations
Sastry CSP and Naidu PY
Microchimica Acta, 127(3-4), 219-223 (1997)
Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection
Verma KK, et al.
Analyst, 116(6), 641-645 (1991)
Fumaric acid: a new feed additive for pigs.
Nutrition reviews, 43(8), 253-254 (1985-08-01)
Fumaric acid esters, their place in the treatment of psoriasis.
A D Ormerod et al.
The British journal of dermatology, 150(4), 630-632 (2004-04-22)
R Gold et al.
Clinical immunology (Orlando, Fla.), 142(1), 44-48 (2011-03-19)
Fumaric acid was originally therapeutically used in psoriasis. Several lines of evidence have demonstrated immunomodulatory but also neuroprotective effects for FAE. Clinical studies in psoriasis showed a reduction of peripheral CD4+ and CD8+ T-lymphocytes due to the ability of FAE
商品
A new RP-HPLC method is proposed for the determination of organic acids in 100% aqueous mobile phase using an Ascentis® Express AQ-C18 column
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