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Merck
CN

PHR1243

Supelco

鸟嘌呤

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
2-乌嘌呤, 2-氨基-1,7-二氢-6H-嘌呤-6-酮, 2-氨基-6-羟基嘌呤
经验公式(希尔记法):
C5H5N5O
CAS号:
分子量:
151.13
Beilstein:
9680
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to BP 879
traceable to USP 1302156

API类

ganciclovir, valacyclovir, aciclovir

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

NC1=Nc2[nH]cnc2C(=O)N1

InChI

1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI key

UYTPUPDQBNUYGX-UHFFFAOYSA-N

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一般描述

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
鸟嘌呤是RNA和DNA合成的构建单元之一,在蛋白生物合成和遗传信息储存中起重要作用。

应用

这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
鸟嘌呤可用作药物参考标准品,用于通过色谱技术测定药物制剂中的分析物。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。所有关于该CRM的信息都可以在分析证书上找到。

附注

要查看该材料的分析证书示例,请在下面的栏位中LRAC0250。这只是一个示例证书,可能不是您收到的批次。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Rapid and simple determination of adenine and guanine in DNA extract by micellar electrokinetic chromatography with indirect laser-induced fluorescence detection
Wang W, et al.
Talanta, 74(4), 1050-1055 (2008)
Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets
Monajjemzadeh F, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 73(3), 404-413 (2009)
Zac Chatterton et al.
Clinical chemistry, 60(7), 995-1003 (2014-05-16)
DNA methylation biomarkers capable of diagnosis and subtyping have been found for many cancers. Fifteen such markers have previously been identified for pediatric acute lymphoblastic leukemia (ALL). Validation of these markers is necessary to assess their clinical utility for molecular
Wieneke A Buikhuisen et al.
The Lancet. Oncology, 14(6), 543-551 (2013-04-16)
Standard chemotherapy does not lead to long-term survival in patients with malignant pleural mesothelioma. Malignant pleural mesothelioma is strongly dependent on vasculature with high vessel counts and high concentrations of serum vascular growth factors. Thalidomide has shown antiangiogenic activity, and
S Kawanishi et al.
Mutation research, 488(1), 65-76 (2001-02-27)
Reactive species generated by chemicals and UV radiation can cause sequence-specific DNA damage and play important roles in mutagenesis, carcinogenesis and aging. We have investigated sequence specificity of oxidative stress-mediated DNA damage by using 32P-labeled DNA fragments obtained from the

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