PHR1233
生物素
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
D-生物素, Bios II, 维生素B7, 维生素H, 辅酶 R
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关于此项目
经验公式（希尔记法）:
C10H16N2O3S
化学文摘社编号:
分子量:
244.31
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-399-3
Beilstein/REAXYS Number:
86838
MDL number:
产品名称
生物素, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChI key
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
SMILES string
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. B1116000
traceable to USP 1071508
API family
biotin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
231-233 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Application
生物素可作为药物参考标准品，通过生物传感系统和色谱技术对药物制剂中的分析物进行测定。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
General description
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
生物素是一种水溶性维生素，是氨基酸和碳水化合物代谢所必需的。它参与嘌呤核苷酸的从头合成，并在基因表达和DNA复制中发挥作用。
生物素是一种水溶性维生素，是氨基酸和碳水化合物代谢所必需的。它参与嘌呤核苷酸的从头合成，并在基因表达和DNA复制中发挥作用。
Other Notes
要查看该材料的分析证书示例，请在下面的栏位中输入 LRAC0265。这只是一个示例证书，可能不是您收到的批次。
该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Determination of biotin in foodstuffs and pharmaceutical preparations using a biosensing system based on the streptavidin--biotin interaction.
Reyes FD, et al.
Analytica Chimica Acta, 436(1), 109-117 (2001)
Using of HPLC coupled with coulometric detector for the determination of biotin in pharmaceuticals.
Zerzanova A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(5), 730-735 (2007)
Liquid chromatographic determination of biotin in multivitamin-multimineral tablets.
Ekpe AE and Hazen C
Journal of Pharmaceutical and Biomedical Analysis, 16(8), 1311-1315 (1998)
Yuxi Feng et al.
PloS one, 6(2), e16865-e16865 (2011-03-08)
Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in
Sung Jae Shin et al.
Clinical and vaccine immunology : CVI, 15(8), 1277-1281 (2008-06-14)
We previously reported that protein antigens of serodiagnostic potential were more abundant in culture filtrates than cellular extracts from liquid cultures of Mycobacterium avium subsp. paratuberculosis (D. Cho and M. T. Collins, Clin. Vaccine Immunol. 13:1155-1161, 2006). Based on this
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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