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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1187091
API类
dibutyl sebacate
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
折射率
n20/D 1.441 (lit.)
沸点
178-179 °C/3 mmHg (lit.)
密度
0.936 g/mL at 25 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
CCCCOC(=O)CCCCCCCCC(=O)OCCCC
InChI
1S/C18H34O4/c1-3-5-15-21-17(19)13-11-9-7-8-10-12-14-18(20)22-16-6-4-2/h3-16H2,1-2H3
InChI key
PYGXAGIECVVIOZ-UHFFFAOYSA-N
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一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAA9029 in the slot below. This is an example certificate only and may not be the lot that you receive.
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
366.8 °F - open cup
闪点(°C)
186 °C - open cup
Burdock AG et al.
Encyclopedia of Food & Color Additives, 1 (1997)
E Oh et al.
International journal of pharmaceutics, 188(2), 203-219 (1999-10-16)
The surface free energy parameters of ethylcellulose (EC) films were determined using the Lifshitz-van der Waals/acid-base approach and the influence of plasticizers on their surface energetics was assessed. Films were prepared by dip-coating glass slides in organic solvents containing EC
D Serp et al.
Biotechnology and bioengineering, 82(1), 103-110 (2003-02-06)
The bioconversion of L-phenylalanine to 2-phenylethanol by Saccharomyces cerevisiae in fed-batch experiments has shown that concentrations of 2-phenylethanol of >2.9 g/L have a negative impact on the oxidative capacity of the yeast. Without tight control on ethanol production, and hence
Sogol Kangarlou et al.
International journal of pharmaceutics, 356(1-2), 153-166 (2008-03-22)
This research was conducted to investigate the physico-mechanical characteristics of the EC-based coating membranes plasticized with two informal ingredients of vitamin resources, cholecalciferol and alpha-tocopherol, with respect to the commercial plasticizer DBS. Proceeding the experiment, free thin polymer sheetings of
A Wyss et al.
Biotechnology and bioengineering, 91(2), 227-236 (2005-05-26)
The activity of penicillin acylase has been studied in aqueous and organic solvents, as free enzyme as well as immobilized within the membrane of liquid-core capsules. The activity of the enzyme is inhibited by the accumulation of the products of
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