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Merck
CN

PHR1216

Supelco

癸二酸二丁酯

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
癸二酸二正丁酯, 皮脂酸二丁酯
线性分子式:
[-(CH2)4CO2(CH2)3CH3]2
CAS号:
分子量:
314.46
Beilstein:
1798308
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1187091

API类

dibutyl sebacate

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

折射率

n20/D 1.441 (lit.)

bp

178-179 °C/3 mmHg (lit.)

密度

0.936 g/mL at 25 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CCCCOC(=O)CCCCCCCCC(=O)OCCCC

InChI

1S/C18H34O4/c1-3-5-15-21-17(19)13-11-9-7-8-10-12-14-18(20)22-16-6-4-2/h3-16H2,1-2H3

InChI key

PYGXAGIECVVIOZ-UHFFFAOYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA9029 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

WGK

WGK 1


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Burdock AG et al.
Encyclopedia of Food & Color Additives, 1 (1997)
D Serp et al.
Biotechnology and bioengineering, 82(1), 103-110 (2003-02-06)
The bioconversion of L-phenylalanine to 2-phenylethanol by Saccharomyces cerevisiae in fed-batch experiments has shown that concentrations of 2-phenylethanol of >2.9 g/L have a negative impact on the oxidative capacity of the yeast. Without tight control on ethanol production, and hence
Sogol Kangarlou et al.
International journal of pharmaceutics, 356(1-2), 153-166 (2008-03-22)
This research was conducted to investigate the physico-mechanical characteristics of the EC-based coating membranes plasticized with two informal ingredients of vitamin resources, cholecalciferol and alpha-tocopherol, with respect to the commercial plasticizer DBS. Proceeding the experiment, free thin polymer sheetings of
E Oh et al.
International journal of pharmaceutics, 188(2), 203-219 (1999-10-16)
The surface free energy parameters of ethylcellulose (EC) films were determined using the Lifshitz-van der Waals/acid-base approach and the influence of plasticizers on their surface energetics was assessed. Films were prepared by dip-coating glass slides in organic solvents containing EC
T Quinten et al.
Drug development and industrial pharmacy, 37(2), 149-159 (2010-07-10)
It was the aim of the present study to develop sustained-release matrix tablets by means of injection molding of ethylcellulose (EC) and polyethylene oxide (PEO) mixtures and to evaluate the influence of process temperature, matrix composition, and viscosity grade of

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