PHR1210
枯烯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
2-苯丙烷, NSC 8776, 异丙基苯, （1-甲基乙基）苯
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线性分子式:
C6H5CH(CH3)2
化学文摘社编号:
分子量:
120.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
202-704-5
Beilstein/REAXYS Number:
1236613
MDL number:
产品名称
枯烯, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C9H12/c1-8(2)9-6-4-3-5-7-9/h3-8H,1-2H3
InChI key
RWGFKTVRMDUZSP-UHFFFAOYSA-N
SMILES string
CC(C)c1ccccc1
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1151709
vapor density
4.1 (vs air)
vapor pressure
8 mmHg ( 20 °C)
9.7 mmHg ( 37.7 °C)
API family
cumene
CofA
current certificate can be downloaded
autoignition temp.
797 °F
expl. lim.
6.5 %
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.491 (lit.)
bp
152-154 °C (lit.)
mp
−96 °C (lit.)
density
0.864 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
Cumene may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9023 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Asp. Tox. 1 - Carc. 1B - Flam. Liq. 3 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
87.8 °F - closed cup
flash_point_c
31.0 °C - closed cup
法规信息
危险化学品
此项目有
A novel peroxy radical based oxidative stressing system for ranking the oxidizability of drug substances
Harmon PA. et al.
Journal of Pharmaceutical Sciences, 95(9), 2014-2028 (2006)
Determination of Residual Solvents in Bulk Drug and Formulations
Singh P and Sinha M
American Journal of PharmTech Research, 3(4), 289-295 (2006)
Sibylle Schliemann et al.
Contact dermatitis, 65(2), 107-114 (2011-06-23)
Neurosensory irritation is a subjective phenomenon induced by a number of chemicals. Objectives. To investigate the sensory irritation induced by two organic solvents - n-octane and cumene - between two groups of volunteers, stingers and non-stingers, identified as such according
Sibylle Schliemann et al.
Contact dermatitis, 63(6), 347-356 (2010-11-03)
Skin exposure to lipophilic irritants at workplaces is a risk factor for the development of occupational irritant hand dermatitis. Suitable lipophilic model irritants to be used in repeated irritation studies in volunteers are needed to gain a better understanding of
Mathieu Frenette et al.
Journal of the American Chemical Society, 128(51), 16432-16433 (2006-12-21)
A new class of thermally activated chain-breaking antioxidants is presented. Dimers of persistent carbon-centered radicals are able to inhibit the autoxidation of cumene and styrene with better rate constants than the commercial antioxidant Irganox HP-136 and 3,5-di-tert-butyl-4-hydroxyanisole. A dramatic increase
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