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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to BP 76
traceable to Ph. Eur. C1700000
traceable to USP 1121005
API类
chlorothiazide
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
InChI
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChI key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
基因信息
human ... SLC12A3(6559)
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一般描述
Chlorothiazide belongs to the class of thiazide diuretic drugs. It is used for the management of postparturient udder edema in cattle. Its mode of action involves the inhibition of chloride reabsorption in the proximal portion of distal tubule.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Chlorothiazide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
One of the first in the thiazide class of diuretics.
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAA8998 in the slot below. This is an example certificate only and may not be the lot that you receive.
推荐产品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Chlorothiazide
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 29(5), 942-942 (2019)
Pharmacologic Adjuncts I
Assisted Ventilation of the Neonate, 311-328 (2003)
Liquid chromatographic determination of chlorothiazide and hydrochlorothiazide diuretic drugs in bovine milk
Shaikh B and Rummel N
Journal of Agricultural and Food Chemistry, 46(3), 1039-1043 (1998)
Liquid chromatography in pharmaceutical analysis II: Determination of a reserpine?chlorothiazide mixture
Honigberg IL, et al.
Journal of Pharmaceutical Sciences, 63(11), 1762-1764 (1974)
Validated micellar electrokinetic capillary chromatography method for quality control of the drug substances hydrochlorothiazide and chlorothiazide
Thomas BR, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 657(2), 383-394 (1994)
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