PHR1173
N-乙酰-L-酪氨酸
Pharmaceutical Secondary Standard; Certified Reference Material
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关于此项目
线性分子式:
4-(HO)C6H4CH2CH(NHCOCH3)CO2H
化学文摘社编号:
分子量:
223.23
NACRES:
NA.24
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
41116107
EC Number:
208-671-3
MDL number:
Beilstein/REAXYS Number:
2697172
InChI key
CAHKINHBCWCHCF-JTQLQIEISA-N
InChI
1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1
SMILES string
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1010106
API family
acetyltyrosine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
Quality Level
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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General description
N-乙酰基-L-酪氨酸是氨基酸L-酪氨酸的乙酰基衍生物。与L-酪氨酸相比，它易溶于水，通常用作注射营养补充剂。
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
Application
N-乙酰基-L-酪氨酸可用作药物标准品，用于通过滴定分析和高效液相色谱法测定散装药物和药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
分析物的数值在批次间变化很大。
想要查看本品的检验报告示例，请在下框中输入LRAA6108。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
N-Acetyltyrosine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 1641-1642 (2017)
N-Acetyltyrosine
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 38(3)(5), 4702-4702 (2018)
Wei Xie et al.
Journal of inorganic biochemistry, 103(1), 58-63 (2008-10-25)
Complexes of the uranyl cation [UO(2)(2+)] with histidine (His), N-acetyl-histidine (NAH), tyrosine (Tyr), and N-acetyl-tyrosine (NAT) were studied by UV-visible and NMR spectroscopy, and by potentiometric titration. Protonation constants for each ligand are reported, as are cumulative formation constants for
G Drabik et al.
Acta biochimica Polonica, 48(1), 271-275 (2001-07-07)
N-acetyl-L-tyrosine (N-acTyr), with the alpha amine residue blocked by acetylation, can mimic the reactivity of exposed tyrosyl residues incorporated into polypeptides. In this study chlorination of N-acTyr residue at positions 3 and 5 in reactions with NaOCl, chloramines and the
Sandrine Perrier et al.
Journal of the American Chemical Society, 131(34), 12458-12465 (2009-08-08)
Steady-state (1)H photo-chemically induced dynamic nuclear polarization (CIDNP) experiments were conducted at 14.1 T on deoxygenated (buffered pH 7) aqueous solutions of [Ru(phen)(3)](2+), [Ru(tap)(2)(phen)](2+), and [Ru(tap)(3)](2+) (tap = 1,4,5,8-tetraazaphenanthrene; phen = 1,10-phenanthroline) in the presence of guanosine-5'-monophosphate or N-acetyltyrosine. For
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