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文件

PHR1164

Supelco

盐酸胺碘酮 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
2-丁基-3-苯并呋喃基-4-[2-（二乙氨基）乙氧基]-3,5-二碘苯基酮 盐酸盐, （2-丁基-3-苯并呋喃基） [4-[2-（二乙氨基）乙氧基]-3,5-二碘苯基] 甲酮 盐酸盐
经验公式（希尔记法）:
C25H29I2NO3 · HCl
CAS号:
19774-82-4
分子量:
681.77
EC 号:
243-293-2
MDL编号:
MFCD00069204
UNSPSC代码:
41116107
PubChem化学物质编号:
329823181
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 532
traceable to Ph. Eur. A0575000
traceable to USP 1027302

API类

amiodarone

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl

InChI

1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

InChI key

ITPDYQOUSLNIHG-UHFFFAOYSA-N

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Amiodarone hydrochloride is an antiarrhythmic drug used for the treatment of ventricular and supraventricular tachycardia.

应用

Amiodarone hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
非选择性离子通道阻滞剂

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3555 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

Y0000129

胺碘酮杂质D, European Pharmacopoeia (EP) Reference Standard

Y0000130

胺碘酮杂质E, European Pharmacopoeia (EP) Reference Standard

A0575000

盐酸胺碘酮 盐酸盐, European Pharmacopoeia (EP) Reference Standard

1027302

盐酸胺碘酮 盐酸盐, United States Pharmacopeia (USP) Reference Standard

1027346

Amiodarone Related Compound D, United States Pharmacopeia (USP) Reference Standard

1027357

Amiodarone Related Compound E, United States Pharmacopeia (USP) Reference Standard

1027380

2-二乙氨基氯乙烷 盐酸盐, United States Pharmacopeia (USP) Reference Standard

BP532

盐酸胺碘酮 盐酸盐, British Pharmacopoeia (BP) Reference Standard

BP531

(2-Butylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone, British Pharmacopoeia (BP) Reference Standard

PHR1646

胺碘酮相关化合物 H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2415

Amiodarone Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2416

Amiodarone Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

警示用语：

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Minhui Wang et al.
Pharmacological reports : PR, 66(6), 1022-1030 (2014-12-03)
The antiarrhythmic potential of a novel multichannel blocker CPUY102122 (CY22) was investigated in the present study. The effect of CY22 on rapid delayed rectifier potassium channel current (IKr) was studied using whole-cell patch clamp techniques in Chinese Hamster Ovary cells
S Karmarkar et al.
Journal of pharmaceutical and biomedical analysis, 100, 167-174 (2014-08-30)
The USP monograph describes an HPLC method for seven impurities in the amiodarone drug substance using a L1 column, 4.6mm×150mm, 5μm packing (PF listed ODS2 GL-Science, Inertsil column) at 30°C with detection at 240nm. The standard contains 0.01mg/mL of amiodarone

实验方案

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

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