PHR1158
苯佐卡因
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-氨基苯甲酸乙酯, 对氨基苯甲酸乙酯
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经验公式（希尔记法）:
C9H11NO2
化学文摘社编号:
分子量:
165.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
202-303-5
Beilstein/REAXYS Number:
638434
MDL number:
产品名称
苯佐卡因, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
BLFLLBZGZJTVJG-UHFFFAOYSA-N
InChI
1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
SMILES string
CCOC(=O)c1ccc(N)cc1
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1054000
API family
benzocaine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Benzocaine may be used as a pharmaceutical reference standard for the determination of the analyte in bioadhesive gel, pharmaceutical formulations and channel catfish tissues by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzocaine is an ester-type local anesthetic, able to induce pain relief. It is used extensively in topical, mucosal and dermal formulations.
Benzocaine is an ester-type local anesthetic, able to induce pain relief. It is used extensively in topical, mucosal and dermal formulations.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6506 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
233.6 °F
flash_point_c
112 °C
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.
Perez-Lozano P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(5), 920-927 (2005)
Separation and simultaneous high-performance liquid chromatographic determination of benzocaine and benzyl benzoate in a pharmaceutical preparation.
Gigante B, et al.
Journal of Chromatography A, 549(5), 217-220 (1991)
A Szoke et al.
Journal of pharmaceutical and biomedical analysis, 16(1), 69-75 (1998-02-03)
Methods for extraction and gradient HPLC quantification were developed for benzocaine (BZ) and three of its metabolites to be used in conjunction with a reverse isotope technique. The metabolites were p-aminobenzoic acid (PABA), acetyl-p-aminobenzoic acid (AcPABA) and acetylbenzocaine (AcBZ). The
Qing Zhu et al.
Molecular pharmaceutics, 9(3), 546-553 (2012-02-04)
The crystallization kinetics of various active pharmaceutical ingredient/polyethylene glycol (API/PEG) solid dispersions has been investigated using wide-angle X-ray diffraction (XRD) and Raman spectroscopy. APIs with different physicochemical properties and crystallization tendency were employed to form solid dispersions with PEG. The
Nathalie Ferreira Silva De Melo et al.
Journal of pharmaceutical sciences, 101(3), 1157-1165 (2011-11-23)
This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(D,L-lactide-co-glycolide), poly(L-lactide) (PLA), and poly(ε-caprolactone) and used as carrier systems for the local anesthetic (LA) benzocaine (BZC). The systems were characterized and their anesthetic activities investigated.
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