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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1534209
API类
phenyl salicylate
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
沸点
172-173 °C/12 mmHg (lit.)
mp
~Approximately 42 °C
41-43 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
Oc1ccccc1C(=O)Oc2ccccc2
InChI
1S/C13H10O3/c14-12-9-5-4-8-11(12)13(15)16-10-6-2-1-3-7-10/h1-9,14H
InChI key
ZQBAKBUEJOMQEX-UHFFFAOYSA-N
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一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Phenyl salicylate is a phenyl ester of salicylic acid and is used as a medicine under the name ′salol′ as an internal antiseptic. It finds its application in paints, waxes, and varnishes as it is found to absorb UV radiation in the range of 290-325 nm. It also shows its presence in cosmetics and sunscreens as a UV filter.
Phenyl salicylate is a phenyl ester of salicylic acid and is used as a medicine under the name ′salol′ as an internal antiseptic. It finds its application in paints, waxes, and varnishes as it is found to absorb UV radiation in the range of 290-325 nm. It also shows its presence in cosmetics and sunscreens as a UV filter.
应用
Phenyl salicylate may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
附注
To see an example of a Certificate of Analysis for this material enter LRAA7176 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语:
Warning
危险分类
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
230.0 °F - closed cup
闪点(°C)
110 °C - closed cup
An examination of the thermodynamics of fusion, vaporization, and sublimation of several parabens by correlation gas chromatography
Journal of Pharmaceutical Sciences, 100(5), 1847-1855 (2011)
Chemical analysis and ecotoxicological effects of organic UV-absorbing compounds in aquatic ecosystems
TrAC, Trends in Analytical Chemistry, 28(6), 708-717 (2009)
Selective synthesis of phenyl salicylate (salol) by esterification reaction over solid acid catalysts
J. Mol. Catal. A: Chem., 223(1-2), 155-159 (2004)
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 936(6), 80-87 (2013)
Use of 1H NMR to facilitate solubility measurement for drug discovery compounds
International Journal of Pharmaceutics, 369(1-2), 47-52 (2009)
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