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主要文件

PHR1149

Supelco

对乙酰氨基酚相关化合物J

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

4′-氯乙酰苯胺, 4-氯乙酰苯胺, N-(4-氯苯基)乙酰胺, NSC 40563, NSC 444

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1 AMP
¥483.72

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预计发货时间2025年9月15日详情


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1 AMP
¥483.72

About This Item

线性分子式:
CH3CONHC6H4Cl
CAS号:
分子量:
169.61
Beilstein:
509638
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

¥483.72


预计发货时间2025年9月15日详情


获取大包装报价

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to Ph. Eur. Y0001945
traceable to USP 1003100

API类

paracetamol, acetaminophen

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

176-178 °C (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

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此商品
P9599P8340P8215
form

DMSO solution

form

DMSO solution

form

DMSO solution

form

DMSO solution

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

一般描述

该认证标准物质(CRM)根据ISO 17034和ISO/IEC 17025生产和认证。有关本CRM用途的所有信息参见分析证书。

用于质量控制的药物二级标准品,为制药实验室和制造商制备内部工作标准提供了一种方便、高性价比的替代方案。

它是广泛使用的退烧及镇痛药对乙酰氨基酚(也称扑热息痛)的杂质。[1]

应用

该药物二级标准品也可用于以下应用:

  • 通过高效液相色谱(HPLC)分离和评估市售对乙酰氨基酚片中的对乙酰氨基酚及其工艺杂质[1]
  • 开发和确认基于HPLC的稳定性指示方法用于测定非处方糖浆制剂中的对乙酰氨基酚、马来酸氯苯吡胺及其可能的分解产物[2]
  • 采用四种基于化学计量的分光光度法检测和定量测定对乙酰氨基酚、盐酸去氧肾上腺素和对乙酰氨基酚杂质
  • 采用离子对反相液相色谱结合紫外检测分析对乙酰氨基酚、半水磷酸可待因和吡托非农盐酸盐的复方栓剂中的杂质[3]
  • 开发薄层色谱结合密度测定的方法用于分离商业剂型中的对乙酰氨基酚及其相关杂质 [4]

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

分析物的数值在批次间变化很大。

附注

想要查看本品的检验报告示例,请在下框中输入LRAC0397。这只是一个示例证书,可能与您收到的批次不符。

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象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Simultaneous Estimation of Acetaminophen, Chlorpheniramine Maleate, Methyl Paraben, Propyl Paraben, Sodium Benzoate and Related Impurities in Over-the-Counter Syrup Formulation
    Palakurthi AK and Dongala T
    Pharmaceutical Chemistry Journal, 1-7 (2022)
    Alina Pyka et al.
    BioMed research international, 2013, 545703-545703 (2013-09-26)
    Adsorption thin layer chromatography (NP-TLC) with densitometry has been established for the identification and the quantification of acetaminophen in three leading commercial products of pharmaceutical tablets coded as brand: P1 (Product no. 1), P2 (Product no. 2), and P3 (Product
    L Koymans et al.
    Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 633-648 (1993-06-01)
    1. The general mechanism of metabolic oxidation of substrates by cytochromes P450 (P450s) appears to consist of sequential one-electron oxidation steps rather than of a single concerted transfer of activated oxygen species from P450 to substrates. 2. In case of
    Tamas A Godany et al.
    Chimia, 65(4), 253-255 (2011-06-18)
    Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of
    Anthony F Pizon et al.
    Clinical toxicology (Philadelphia, Pa.), 47(2), 132-136 (2008-07-09)
    p-Chloroaniline is more potent at producing methemoglobin than aniline in animal models. This case highlights the clinical presentation of an inhalation exposure to p-chloroaniline and associated laboratory analysis. An in-vitro study evaluating the metabolism of p-chloroaniline in human hepatocytes was

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