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Merck
CN

PHR1148

对乙酰氨基酚相关化合物K

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

4-氨基苯酚, 4-羟苯胺

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线性分子式:
H2NC6H4OH
化学文摘社编号:
123-30-8
分子量:
109.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823166
EC Number:
204-616-2
Beilstein/REAXYS Number:
385836
MDL number:
MFCD00007869

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产品名称

对乙酰氨基酚相关化合物K, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

PLIKAWJENQZMHA-UHFFFAOYSA-N

InChI

1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

SMILES string

Nc1ccc(O)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001955
traceable to USP 1021204

API family

mesalazine, paracetamol, acetaminophen

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

185-189 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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相关类别

Application

该药物二级标准品也可用于以下应用：
  • 通过高效液相色谱（HPLC）分离和评估市售对乙酰氨基酚片中的对乙酰氨基酚及其工艺杂质
  • 采用还原氧化石墨烯-氮化钛（RGO-TiN）纳米杂化物进行对乙酰氨基酚及其杂质K的同时电化学测定
  • 开发和确认基于HPLC的稳定性指示方法用于测定非处方糖浆制剂中的对乙酰氨基酚、马来酸氯苯吡胺及其可能的分解产物
  • 通过高效薄层色谱（HPTLC）和反相高效液相色谱（RP-HPLC）根据ICH指南测定复方片剂中的对乙酰氨基酚、帕马溴及其杂质
  • 通过薄层色谱（TLC）-密度测定方法进行复方胶囊中对乙酰氨基酚、氯唑沙宗及其主要分解杂质的组合分析

General description

该认证标准物质（CRM）根据ISO 17034和ISO/IEC 17025生产和认证。有关本CRM用途的所有信息参见分析证书。

用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准提供了一种方便、高性价比的替代方案。

它是广泛使用的退烧及镇痛药对乙酰氨基酚（也称扑热息痛）的主要分解产物，通过水解形成。

Other Notes

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
想要查看本品的分析证书示例，请在下框中输入LRAC3043 。这只是一个示例证书，可能与您收到的批次不符。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2

target_organs

Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

危险化学品
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Facile green synthesis of graphene-titanium nitride hybrid nanostructure for the simultaneous determination of acetaminophen and 4-aminophenol
Kong F-Y, et al.
Sensors and Actuators B, Chemical, 213, 397-403 (2015)
Simultaneous Estimation of Acetaminophen, Chlorpheniramine Maleate, Methyl Paraben, Propyl Paraben, Sodium Benzoate and Related Impurities in Over-the-Counter Syrup Formulation
Palakurthi AK and Dongala T
Pharmaceutical Chemistry Journal, 1-7 (2022)
Y Xu et al.
Clinical chemistry, 36(11), 1941-1944 (1990-11-01)
A sandwich-type heterogeneous enzyme immunoassay with flow-injection analysis for alpha-fetoprotein (AFP) in human serum has been developed. 4-Aminophenol, the product of enzymatic reaction, is detected amperometrically. The interassay CV for this electrochemical enzyme immunoassay was less than 8.2%, with a
E P Gil et al.
Clinical chemistry, 36(4), 662-665 (1990-04-01)
A competitive enzyme-linked immunoabsorbent assay based on the flow-injection amperometric detection of p-aminophenol has been investigated with use of the materials and general procedure of a commercial kit for the determination of theophylline in human serum. The antibody is immobilized
Octavian Călinescu et al.
Journal of chromatographic science, 50(4), 335-342 (2012-03-13)
Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil
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