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PHR1088

Supelco

阿齐霉素

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

阿齐霉素 二水合物

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About This Item

经验公式（希尔记法）:
C38H72N2O12 · 2H2O
CAS号:
117772-70-0
分子量:
785.02
MDL编号:
MFCD01862248
UNSPSC代码:
41116107
PubChem化学物质编号:
329823110
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0000306
traceable to USP 1046056

API类

azithromycin

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

-10 to -25°C

SMILES字符串

O.O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1

InChI key

SRMPHJKQVUDLQE-KUJJYQHYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Azithromycin may be used as a pharmaceutical reference standard for the determination of the analyte in plasma/serum samples and pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Azithromycin dihydrate is a macrolide antibiotic with anti-immunomodulatory/anti-inflammatory properties.
Azithromycin dihydrate is a macrolide antibiotic, azalide subclass. It binds to the 50S subunit of the 70S bacterial ribosomes and inhibits RNA-dependent protein synthesis in bacterial cells. Azithromycin also has anti-immunomodulatory/anti-inflammatory properties, which make it useful in treating cystic fibrosis.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB3758 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

Y0000306

阿奇霉素, European Pharmacopoeia (EP) Reference Standard

Y0000637

阿齐霉素 二水合物, European Pharmacopoeia (EP) Reference Standard

Y0000641

阿齐霉素 二水合物, European Pharmacopoeia (EP) Reference Standard

1046067

鉴定用阿奇霉素, United States Pharmacopeia (USP) Reference Standard

Y0000307

阿奇霉素杂质 A, European Pharmacopoeia (EP) Reference Standard

1046090

Azithromycin N-oxide, United States Pharmacopeia (USP) Reference Standard

1046045

Azithromycin Related Compound F, United States Pharmacopeia (USP) Reference Standard

1045600

阿奇霉素A, United States Pharmacopeia (USP) Reference Standard

1046078

Desosaminylazithromycin, United States Pharmacopeia (USP) Reference Standard

1046089

N-Demethylazithromycin, United States Pharmacopeia (USP) Reference Standard

1046023

Azithromycin Related Compound H, United States Pharmacopeia (USP) Reference Standard

PHR2625

Desosaminylazithromycin, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2780

阿奇霉素A, pharmaceutical secondary standard, certified reference material

PHR2781

3′-N-Demethyl-3′-N-formylazithromycin, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2782

Azithromycin N-oxide, certified reference material, pharmaceutical secondary standard

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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LC determination of impurities in azithromycin tablets
Miguel L and Barbas C
Journal of Pharmaceutical and Biomedical Analysis, 33(2), 211-217 (2003)
Determination of erythromycin, clarithromycin, roxithromycin, and azithromycin in plasma by high-performance liquid chromatography with amperometric detection
Taninaka C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 738(2), 405-411 (2000)
Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by high-performance liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl chloride and fluorescence detection
Torano JS and Guchelaar HJ
Journal of Chromatography. B, Biomedical Sciences and Applications, 720(1-2), 89-97 (1998)
Mark A Turner et al.
Archives of disease in childhood, 97(6), 573-577 (2011-06-24)
Chronic lung disease of prematurity (CLD) remains a major cause of morbidity and mortality in preterm infants. Ureaplasma has received intermittent attention over the last two decades as a possible contributory factor. In addition, pulmonary inflammation is associated with the
Anna M van Eijk et al.
The Cochrane database of systematic reviews, (2)(2), CD006688-CD006688 (2011-02-18)
To prevent the development of drug resistance, the World Health Organization (WHO) recommends treating malaria with combination therapy. Azithromycin, an antibiotic with antimalarial properties, may be a useful additional option for antimalarial therapy. To compare the use of azithromycin alone
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