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PHR1081

水杨酸乙基己酯

Name: 水杨酸乙基己酯
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

水杨酸-2-乙基己基酯, 柳酸辛酯, 水杨酸辛酯

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About This Item

线性分子式:

(HO)C₆H₄CO₂CH₂CH(C₂H₅)(CH₂)₃CH₃

CAS号:

118-60-5

分子量:

250.33

Beilstein:

2730664

EC 号:

204-263-4

MDL编号:

MFCD00053300

UNSPSC代码:

41116107

PubChem化学物质编号:

329823104

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1477943

API类

octisalate

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

折射率

n20/D 1.502 (lit.)

bp

189-190 °C/21 mmHg (lit.)

密度

1.014 g/mL at 25 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CCCCC(CC)COC(=O)c1ccccc1O

InChI

1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

InChI key

FMRHJJZUHUTGKE-UHFFFAOYSA-N

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一般描述

水杨酸辛酯（Octisalate ）是一种防晒剂，可充当UVB（280-315 nm）辐射的UV过滤剂。
用于质量控制的药物二级标准品CRM，为制药行业实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

应用

水杨酸辛酯可用作药物参考标准品，用于通过色谱法测定药物和防晒霜制剂中的分析物。

这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

分析说明

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

其他说明

本有证标准物质 (CRM) 按照 ISO 17034 和 ISO/IEC 17025 生产和认证。有关本 CRM 使用的所有信息，请参见检验报告。

附注

想要查看本品的分析证书示例，请在下框中输入LRAC0298。这只是一个示例证书，可能与您收到的批次不符。

1477943

水杨酸辛酯, United States Pharmacopeia (USP) Reference Standard

象形图

GHS09

警示用语：

Warning

危险声明

H410

预防措施声明

P273 - P391 - P501

危险分类

Aquatic Chronic 1

WGK

WGK 2

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分析证书(COA)

Lot/Batch Number

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Thin layer chromatography-spray mass spectrometry: a method for easy identification of synthesis products and UV filters from TLC aluminum foils

Himmelsbach M, et al.

Analytical and Bioanalytical Chemistry, 406(15), 3647-3656 (2014)

Octisalate

USP42-NF37: United States Pharmacopeia and National Formulary

United States Pharmacopeia/National Formulary, 43(3), 3194-3194 (2018)

Development and Validation of RP-HPLC Method for Analysis of Four UV Filters in Sunscreen Products

Yousef AN, et al.

International Journal of Pharmaceutical Sciences Review and Research (2013)

Determination of selected organic contaminants in soil by pressurized liquid extraction and gas chromatography tandem mass spectrometry with in situ derivatization.

Beatriz Albero et al.

Journal of chromatography. A, 1248, 9-17 (2012-06-12)

The determination of organic contaminants in soil is a real challenge due to the large number of these compounds with quite different physico-chemical properties. In the present work, an analytical method was developed for the simultaneous determination in soil of

Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro.

K A Walters et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 35(12), 1219-1225 (1998-02-04)

The human skin penetration of [14C]octyl salicylate from two representative sunscreen vehicles was determined in vitro. 3H-sucrose was incorporated into all formulations and provided a marker for membrane integrity. When applied as a finite dose in an oil-in-water emulsion vehicle

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