PHR1081
水杨酸乙基己酯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
水杨酸-2-乙基己基酯, 柳酸辛酯, 水杨酸辛酯
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线性分子式:
(HO)C6H4CO2CH2CH(C2H5)(CH2)3CH3
化学文摘社编号:
分子量:
250.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
204-263-4
Beilstein/REAXYS Number:
2730664
MDL number:
产品名称
水杨酸乙基己酯, Pharmaceutical Secondary Standard; Certified Reference Material
Quality Level
InChI
1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3
InChI key
FMRHJJZUHUTGKE-UHFFFAOYSA-N
SMILES string
CCCCC(CC)COC(=O)c1ccccc1O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1477943
API family
octisalate
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.502 (lit.)
bp
189-190 °C/21 mmHg (lit.)
density
1.014 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
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Application
水杨酸辛酯可用作药物参考标准品，用于通过色谱法测定药物和防晒霜制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
General description
水杨酸辛酯（Octisalate ）是一种防晒剂，可充当UVB（280-315 nm）辐射的UV过滤剂。
用于质量控制的药物二级标准品CRM，为制药行业实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
用于质量控制的药物二级标准品CRM，为制药行业实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
Other Notes
想要查看本品的分析证书示例，请在下框中输入LRAC0298。这只是一个示例证书，可能与您收到的批次不符。
本有证标准物质 (CRM) 按照 ISO 17034 和 ISO/IEC 17025 生产和认证。有关本 CRM 使用的所有信息，请参见检验报告。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
323.6 °F - closed cup
flash_point_c
162 °C - closed cup
Thin layer chromatography-spray mass spectrometry: a method for easy identification of synthesis products and UV filters from TLC aluminum foils
Himmelsbach M, et al.
Analytical and Bioanalytical Chemistry, 406(15), 3647-3656 (2014)
Octisalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 43(3), 3194-3194 (2018)
Development and Validation of RP-HPLC Method for Analysis of Four UV Filters in Sunscreen Products
Yousef AN, et al.
International Journal of Pharmaceutical Sciences Review and Research (2013)
M McVean et al.
Molecular carcinogenesis, 24(3), 169-176 (1999-04-16)
Topical application of alpha-tocopherol (alphaTH), the most prominent naturally occurring form of vitamin E, inhibits ultraviolet (UV) B-induced photocarcinogenesis and DNA photodamage in C3H mice in vivo. In this study, we compared alphaTH with other vitamin E compounds and with
R Jiang et al.
Journal of pharmaceutical sciences, 86(7), 791-796 (1997-07-01)
This study provides an investigation of the availability of octyl salicylate (OS), a common sunscreen agent, from liquid paraffin and the effect of OS on skin permeability. A model membrane system to isolate the vehicle effect from membrane permeability has
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