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安全信息

PHR1076

Supelco

美托洛尔 (+)-酒石酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(±)1-(异丙氨基)-3-[p-(β-甲氧基乙基)苯氧基] -2-丙醇 (+)-酒石酸盐, Lopressor

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About This Item

线性分子式:
(C15H25NO3)2 · C4H6O6
CAS号:
56392-17-7
分子量:
684.81
EC 号:
260-148-9
MDL编号:
MFCD00056257
UNSPSC代码:
41116107
PubChem化学物质编号:
329823099
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 540
traceable to Ph. Eur. M1830000
traceable to USP 1441301

API类

metoprolol

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2

InChI

1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

InChI key

YGULWPYYGQCFMP-CEAXSRTFSA-N

基因信息

human ... ADRB1(153)

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相关类别

一般描述

Metoprolol Tartrate is a β-blocking drug, showing antihypertensive and anti-ischemic effects. It is widely used in the treatment of hypertension and helps in controlling ventricular response in patients with atrial fibrillation.

应用

Metoprolol Tartrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using densitometric technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6905 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

1441301

美托洛尔 (+)-酒石酸盐, United States Pharmacopeia (USP) Reference Standard

Y0000145

美托洛尔杂质A, European Pharmacopoeia (EP) Reference Standard

1441243

Metoprolol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1441254

Metoprolol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1441265

Metoprolol Related Compound D, United States Pharmacopeia (USP) Reference Standard

1441298

Metoprolol succinate, United States Pharmacopeia (USP) Reference Standard

1441232

(±)-1-（乙胺基）-3-[4-（2-甲氧基乙基）苯氧基] -2-丙醇, United States Pharmacopeia (USP) Reference Standard

1441287

Metoprolol fumarate, United States Pharmacopeia (USP) Reference Standard

BP540

美托洛尔 (+)-酒石酸盐, British Pharmacopoeia (BP) Reference Standard

PHR9038

4-(2-甲氧基乙基)苯酚, reference material

PHR9039

2-(4-羟苯基)乙醇, reference material

PHR9068

Metoprolol EP Impurity H, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2509

(±)-1-（乙胺基）-3-[4-（2-甲氧基乙基）苯氧基] -2-丙醇, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9101

Metoprolol EP Impurity E, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2510

Metoprolol Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2511

Metoprolol succinate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3046

Metoprolol Fumarate, pharmaceutical secondary standard, certified reference material

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Warning

危险声明

H361d,H411

危险分类

Aquatic Chronic 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number

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Densitometric determination of metoprolol tartrate in pharmaceutical dosage forms
Vujic Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 15(5), 581-585 (1997)
A validated HPLC method for estimation of metoprolol in human plasma
Aqil M, et al.
Acta Chromatographica , 19, 130-130 (2007)
Current Cardiovascular Drugs, 15(4), 581-585 (2005)
AAS and spectrophotometric determination of propranolol HCl and metoprolol tartrate
El-Ries MA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(2), 179-187 (2000)
C M Blake et al.
Clinical pharmacology and therapeutics, 94(3), 394-399 (2013-05-15)
Metoprolol, a commonly prescribed β-blocker, is primarily metabolized by cytochrome P450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Several smaller studies have shown that metoprolol pharmacokinetics is influenced by CYP2D6 genotype and metabolizer phenotype. To increase robustness of metoprolol
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