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文件

PHR1054

核黄素

Name: 核黄素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(−)-核黄素, 乳黄素, 维生素 B₂, 维生素 G

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About This Item

经验公式（希尔记法）:

C₁₇H₂₀N₄O₆

CAS号:

83-88-5

分子量:

376.36

Beilstein:

97825

EC 号:

201-507-1

MDL编号:

MFCD00005022

UNSPSC代码:

41116107

eCl@ss:

34058005

PubChem化学物质编号:

329823084

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. R060000
traceable to USP 1603006

API类

riboflavin

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

290 °C (dec.) (lit.)

应用

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1

InChI

1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1

InChI key

AUNGANRZJHBGPY-SCRDCRAPSA-N

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一般描述

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

应用

核黄素可作为参考标准品，用于通过各种色谱技术测定熟香肠和能量饮料中的分析物。

这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

分析说明

这些二级标准提供了有效的美国药典、欧洲药典和英国药典一级标准的多重可追溯性。

其他说明

该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

想要查看本品的分析证书示例，请在下框中输入LRAC0268。这只是一个示例证书，可能与您收到的批次不符。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number

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Determination of total riboflavin in cooked sausages

Valls F, et al.

Journal of Agricultural and Food Chemistry, 47(3), 1067-1070 (1999)

Rapid method for determination of riboflavin in urine by high-performance liquid chromatography

Smith DM, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 182(3), 285-291 (1980)

Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry

Aranda M and Morlock G

Journal of Chromatography A, 1131(1-2), 253-260 (2006)

Safety profile of high-fluence corneal collagen cross-linking for progressive keratoconus: preliminary results from a prospective cohort study.

Zisis Gatzioufas et al.

Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 846-848 (2013-10-31)

To investigate the effect of high-fluence corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A in the management of progressive keratoconus. Preliminary results from a prospective cohort study. Seven eyes from 7 patients with progressive keratoconus subjected to CXL were included.

Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.

Carol P Wilson et al.

Hypertension (Dallas, Tex. : 1979), 61(6), 1302-1308 (2013-04-24)

Intervention with riboflavin was recently shown to produce genotype-specific lowering of blood pressure (BP) in patients with premature cardiovascular disease homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR). Whether this effect is

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核黄素