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PHR1039

红霉素

Name: 红霉素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

经验公式（希尔记法）:

C₃₇H₆₇NO₁₃

CAS号:

114-07-8

分子量:

733.93

Beilstein:

75279

EC 号:

204-040-1

MDL编号:

MFCD00084654

UNSPSC代码:

41116107

PubChem化学物质编号:

329823069

NACRES:

NA.24

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Supelco

PHR1610

乙琥红霉素

Sigma-Aldrich

E6376

红霉素

Sigma-Aldrich

E0774

红霉素

USP

1242000

红霉素

Sigma-Aldrich

E5389

红霉素

Y0001912

红霉素

Supelco

PHR1005

对乙酰氨基酚

USP

1242010

Erythromycin B

Supelco

PHR1009

咖啡因

BP781

红霉素

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 794
traceable to Ph. Eur. E1305000
traceable to USP 1242000

API类

erythromycin

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

-10 to -25°C

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Erythromycin is a complex macrolide antibiotic drug that exhibits a bacteriostatic activity. It is generally employed in human and veterinary medicines owing to its potential activity against gram positive and a few gram negative strains.

应用

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Erythromycin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

制备说明

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3047 in the slot below. This is an example certificate only and may not be the lot that you receive.

法律信息

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Fluorimetric determination of erythromycin and erythromycin ethylsuccinate in serum by a high-performance liquid chromatographic post-column, on-stream derivatization and extraction method

Tsuji K

Journal of Chromatography A, 158, 337-348 (1978)

The formulation and stability of erythromycin-benzoyl peroxide in a topical gel

Vermeulen B, et al.

International Journal of Pharmaceutics, 178(1), 137-141 (1999)

Combined use of liquid chromatography with mass spectrometry and nuclear magnetic resonance for the identification of degradation compounds in an erythromycin formulation

Pendela M, et al.

Analytical and Bioanalytical Chemistry, 402(2), 781-790 (2012)

Quantification of erythromycin in pharmaceutical formulation by transmission Fourier transform infrared spectroscopy

Ali.M, et al.

Arabian Journal of Chemistry, 7(6), 1104-1109 (2014)

Microencapsulation of erythromycin and clarithromycin using a spray-drying technique

Zgoulli S, et al.

Journal of Microencapsulation, 16(5), 565-571 (1999)

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主要文件

安全信息

红霉素

Pharmaceutical Secondary Standard; Certified Reference Material

About This Item

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属性

等级

质量水平

Agency

API类

CofA

技术

应用

包装形式

储存温度

SMILES字符串

InChI

InChI key

说明

一般描述

应用

生化/生理作用

注意

制备说明

附注

法律信息

相关产品

相关产品

安全信息

储存分类代码

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

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