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Merck
CN

PHL89262

槲皮素

phyproof® Reference Substance

别名:

2-(3,4-二羟苯基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮, 3,3′,4′,5,6-五羟基黄酮

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About This Item

经验公式(希尔记法):
C15H10O7
CAS号:
分子量:
302.24
Beilstein:
317313
UNSPSC代码:
41116107
NACRES:
NA.24

等级

primary reference standard

产品线

phyproof® Reference Substance

检测方案

≥95.0% (HPLC)

制造商/商品名称

PhytoLab

应用

food and beverages

格式

neat

SMILES字符串

OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1

InChI

1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

InChI key

REFJWTPEDVJJIY-UHFFFAOYSA-N

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一般描述

该物质是具有指定绝对纯度(考虑色谱纯度、水、残留溶剂、无机杂质)的一级参考物质。确切的值见证书。生产商:PhytoLab GmbH & Co. KG

应用


  • Simultaneous determination of eight arginine-related metabolites in cellular extracts using liquid chromatography-tandem mass spectrometry.: This study utilized the Chromolith® RP-18 endcapped column to achieve high-resolution separation of arginine-related metabolites in cellular extracts. The method demonstrated excellent reproducibility and sensitivity, highlighting the column′s effectiveness in complex biological sample analysis (Amatya S et al., 2020).

  • Rapid Determination of 30 Polyphenols in Tongmai Formula, a Combination of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma, via Liquid Chromatography-Tandem Mass Spectrometry.: The Chromolith® RP-18 endcapped column was employed for the rapid and efficient determination of polyphenols in a traditional Chinese medicine formula. The column′s high throughput and robust performance facilitated the simultaneous analysis of multiple compounds, demonstrating its application in natural product research (Wang FR et al., 2017).

  • Simultaneous Liquid Chromatographic Determination of Ebastine with Two Sympathomimetic Drugs Using a Monolithic Column.: This research applied the Chromolith® RP-18 endcapped column to the simultaneous chromatographic determination of ebastine and two sympathomimetic drugs. The study underscored the column′s ability to provide rapid and efficient separations in pharmaceutical analysis, ensuring accurate quantification of drug components (Ibrahim F et al., 2017).


生化/生理作用

槲皮素是一种具有抗癌活性的黄酮类化合物。 槲皮素是一种线粒体ATP酶和磷酸二酯酶抑制剂。它抑制PI3激酶活性,并略抑制PIP激酶活性。槲皮素对癌细胞具有抗增殖作用,通过II型雌激素受体降低癌细胞生长,并在细胞周期G1晚期抑制人白血病T细胞。 槲皮素还可能抑制脂肪酸合酶活性。

其他说明

This compound is commonly found in plants of the genus: allium angelica arnica glycyrrhiza hypericum lycium sambucus

法律信息

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany
phyproof is a registered trademark of PhytoLab GmbH & Co. KG

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

WGK

WGK 3


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Alexandra Vaccaro et al.
Cell, 181(6), 1307-1328 (2020-06-06)
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this

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