P9375
1,10-菲咯啉 一水合物
reagent grade
别名:
邻菲咯啉 一水合物
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关于此项目
经验公式（希尔记法）:
C12H8N2 · H2O
化学文摘社编号:
分子量:
198.22
UNSPSC Code:
12352116
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-629-2
Beilstein/REAXYS Number:
4008096
MDL number:
产品名称
1,10-菲咯啉 一水合物, reagent grade
InChI
1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
InChI key
PPQJCISYYXZCAE-UHFFFAOYSA-N
SMILES string
O.c1cnc2c(c1)ccc3cccnc23
biological source
synthetic (organic)
grade
reagent grade
form
powder
mp
100-104 °C (lit.)
solubility
methanol: 200 mM (Stock solution is stable for months at –20° C.)
Quality Level
Gene Information
human ... FNTA(2339)
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Application
1,10-菲咯啉一水合物用于：
- 用作MDA-MB-231乳腺癌细胞金属蛋白酶（MMP）的抑制剂
- 用作小鼠心脏样本原位酶谱分析的阴性对照品
- 体外白藜芦醇螯合以及螯合铁的还原活性测定
当与铜络合时，具有核酸酶活性，用于研究 DNA-蛋白质相互作用。
Biochem/physiol Actions
金属蛋白酶抑制剂;可与铁、锌和其他二价金属形成螯合物。有效浓度 1-10mM。
General description
菲咯啉是一种杂环有机化合物，可与金属离子形成络合物。这些络合物在生物化学、催化和分析化学领域应用广泛。与铁络合，可作为氧化还原指示剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Katy Satué et al.
Acta veterinaria Hungarica, 68(1), 79-84 (2020-05-10)
In women and females of different species of laboratory animals, oestrogens stimulate the renin-angiotensin-aldosterone system (RAAS) by increasing tissue and circulating levels of angiotensinogen and renin during the preovulatory period. Progesterone and cortisol compete with aldosterone for mineralocorticoid receptors, which
Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans
Soares MV, et al.
Free Radical Research, 52(9), 939-951 (2018)
Central Role of Phenanthroline Mono-N-oxide in the Decomposition Reactions of Tris (1, 10-phenanthroline) iron (II) and-iron (III) Complexes
Beller G, et al.
Inorganic Chemistry, 49(9), 3968-3970 (2010)
Electrochemical and DFT study of the reduction of substituted phenanthrolines
Ferreira H, et al.
Polyhedron, 122, 147-154 (2017)
The transmodulation of HER2 and EGFR by substance P in breast cancer cells requires c-Src and metalloproteinase activation
Garcia-Recio S, et al.
PLoS ONE, 10(6), e0129661-e0129661 (2015)
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