推荐产品
等级
analytical standard
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
Cl.NC(=N)NC(=N)NCCc1ccccc1
InChI
1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H
InChI key
YSUCWSWKRIOILX-UHFFFAOYSA-N
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一般描述
盐酸苯乙双胍是一种双胍衍生物 ,具有抗糖尿病活性。
应用
有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务部门。
盐酸苯乙双胍已用作测试化合物,以研究其在抑制卵巢癌细胞以及人类肝细胞癌细胞生长方面的抗肿瘤活性。
Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs
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Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Biochemical and Biophysical Research Communications, 414(4), 694-699 (2011)
Regulatory toxicology and pharmacology : RTP, 70(2), 514-518 (2014-09-10)
Lactic acidosis occurs in a number of clinical conditions, e.g. in surgeries, orthotopic liver transplant, and anesthetic agent administration, which has deleterious effects on the patient's survival. The most rational therapy for these patients, the sodium bicarbonate administration, cannot prevent
Cell chemical biology, 25(6), 728-737 (2018-04-17)
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle α2β2 AMPK complexes may prove a valuable treatment strategy for type 2 diabetes and insulin resistance. Herein, we report the
Pharmacological research, 140, 21-32 (2018-11-14)
Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use
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