产品名称
维生素 K 1, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
SMILES string
O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O
InChI key
MBWXNTAXLNYFJB-NKFFZRIASA-N
biological source
synthetic
grade
pharmaceutical primary standard
agency
EP
API family
phytomenadione
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
refractive index
n20/D 1.527 (lit.)
mp
−20 °C (lit.)
density
0.984 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
form
viscous liquid
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Application
This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Phytomenadione is a methyl napthoquinone derivative, and a naturally occurring fat soluble vitamin K1. It plays a key role in the maintenance of normal blood clotting mechanism and also in the prevention of hemorrhagic disease in newborns.
Phytomenadione is a methyl napthoquinone derivative, and a naturally occurring fat soluble vitamin K1. It plays a key role in the maintenance of normal blood clotting mechanism and also in the prevention of hemorrhagic disease in newborns.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Clinical Pharmacology, (11) (2012)
Development and validation of spectrophotometric methods for determination of phytomenadione in injection
Patel AS and Parikh KP
Current Research in Pharmaceutical Sciences, 26-30 (2012)
M Kyla Shea et al.
The American journal of clinical nutrition, 98(1), 197-208 (2013-05-31)
Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited. We determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis by using a case-cohort
S L Booth et al.
Thrombosis and haemostasis, 77(3), 504-509 (1997-03-01)
Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the
Niina M Suni et al.
Journal of mass spectrometry : JMS, 47(5), 611-619 (2012-05-12)
In this article, the effect of spray solvent on the analysis of selected lipids including fatty acids, fat-soluble vitamins, triacylglycerols, steroids, phospholipids, and sphingolipids has been studied by two different ambient mass spectrometry (MS) methods, desorption electrospray ionization-MS (DESI-MS) and
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