产品名称
去氧肾上腺素, European Pharmacopoeia (EP) Reference Standard
SMILES string
N(C[C@H](O)c1cc(ccc1)O)C
InChI
1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
InChI key
SONNWYBIRXJNDC-VIFPVBQESA-N
grade
pharmaceutical primary standard
API family
phenylephrine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Uwe Kirchhefer et al.
The Journal of biological chemistry, 289(1), 163-176 (2013-11-15)
Protein phosphatase 2A (PP2A) is a family of multifunctional serine/threonine phosphatases consisting of a catalytic C, a structural A, and a regulatory B subunit. The substrate and therefore the functional specificity of PP2A are determined by the assembly of the
Ashraf S Habib
Anesthesia and analgesia, 114(2), 377-390 (2011-11-23)
Phenylephrine is effective for the management of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery under spinal anesthesia. While ephedrine was previously considered the vasopressor of choice in obstetric patients, phenylephrine is increasingly being used. This is largely due to
A G Tahiliani et al.
General pharmacology, 13(5), 369-374 (1982-01-01)
To summarize, a large number of studies indicate that the effects of phenylephrine on cardiac contractility are mediated through alpha-adrenoceptors, although not exclusively. There are an equally large number of reports indicating some beta-adrenoceptor stimulant effects of phenylephrine. Of the
Hartley C Atkinson et al.
European journal of clinical pharmacology, 71(2), 151-158 (2014-12-06)
Over-the-counter combinations containing acetaminophen and phenylephrine for treatment of the common cold and influenza are widespread, but there are few data about pharmacokinetics of these two drugs used in combination. We aimed to investigate pharmacokinetic interactions between acetaminophen and phenylephrine.
Joseph R H Mauban et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H173-H181 (2014-05-27)
We used two-photon (2-p) Förster resonance energy transfer (FRET) microscopy to provide serial, noninvasive measurements of [Ca(2+)] in arterioles of living "biosensor" mice. These express a genetically encoded Ca(2+) indicator (GECI), either FRET-based exMLCK or intensity-based GCaMP2. The FRET ratios
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