O4630
奥芬那君 柠檬酸盐
analytical standard
别名:
β-二甲基氨基乙基-2-甲基二苯甲醚 柠檬酸盐, 邻甲苯海明 柠檬酸盐
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关于此项目
经验公式（希尔记法）:
C18H23NO · C6H8O7
化学文摘社编号:
分子量:
461.50
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
225-137-5
MDL number:
InChI
1S/C18H23NO.C6H8O6/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-4(8)1-3(6(11)12)2-5(9)10/h4-12,18H,13-14H2,1-3H3;3H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key
XLSFUJUURNFSCL-UHFFFAOYSA-N
SMILES string
OC(=O)CC(CC(O)=O)C(O)=O.CN(C)CCOC(c1ccccc1)c2ccccc2C
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
毒蕈碱型受体拮抗剂；H1 组胺受体拮抗剂；肌肉松弛剂。据报道，奥芬那君还可抑制去甲肾上素转运蛋白并且阻塞 NMDA 受体离子通道。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
M A Saracino et al.
Journal of pharmaceutical and biomedical analysis, 50(3), 501-506 (2009-06-16)
Orphenadrine is an antimuscarinic agent mainly used for the treatment of parkinsonism and to alleviate the neuroleptic syndrome induced by antipsychotic drugs. A new, rapid analytical method, based on liquid chromatography with diode array detection (DAD), has been developed and
Mirosław Czuczwar et al.
Pharmacological reports : PR, 61(4), 732-736 (2009-10-10)
Orphenadrine is an anticholinergic drug used in the treatment of Parkinson's disease, and is also known to exert nonspecific antagonistic activity at the phencyclidine binding site of the N-methyl-D-aspartate (NMDA) receptor. The aim of this study was to assess the
Mei-juan Xu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(7), 730-734 (2007-09-22)
To study the enzyme kinetics of schizandrin metabolism in different gender in rat liver microsomes, liver microsomes were prepared from male or female rats. Schizandrin was incubated with rat liver microsomes. Schizandrin and its metabolites were isolated and identified by
[Interaction of drugs with the primary disease - when medicines exacerbate illnesses].
Anne Taegtmeyer et al.
Praxis, 101(6), 363-370 (2012-03-16)
Bismi Edwin et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 838-846 (2012-08-21)
Vibrational spectral analysis and quantum chemical computations based on density functional theory have been performed on the anti-neuro-degenerative drug Orphenadrine hydrochloride. The geometry, intermolecular hydrogen bond, and harmonic vibrational frequencies of the title molecule have been investigated with the help
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