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Merck
CN
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文件

安全信息

O1378

Supelco

羟考酮标准液 盐酸盐

analytical standard

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经验公式（希尔记法）:
C18H21NO4 · HCl
CAS号:
124-90-3
分子量:
351.82
EC 号:
204-717-1
MDL编号:
MFCD00137583
UNSPSC代码:
41116107
PubChem化学物质编号:
329818896
NACRES:
NA.24

等级

analytical standard

质量水平

200

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

SMILES字符串

Cl.[H][C@@]12Oc3c(OC)ccc4C[C@H]5N(C)CC[C@@]1(c34)[C@@]5(O)CCC2=O

InChI

1S/C18H21NO4.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;/h3-4,13,16,21H,5-9H2,1-2H3;1H/t13-,16+,17+,18-;/m1./s1

InChI key

MUZQPDBAOYKNLO-RKXJKUSZSA-N

基因信息

human ... OPRM1(4988)

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相关类别

一般描述

Oxycodone hydrochloride is an analgesic drug, which is generally used in cancer treatment since it can reduce the pain induced during the treatment.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化/生理作用

μ 和 κ 阿片受体激动剂。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H336

危险分类

Acute Tox. 4 Oral - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

分析证书(COA)

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Rachel E Martin et al.
eNeuro, 8(4) (2021-07-28)
Opioid drugs are increasingly being prescribed to pregnant women. Such compounds can also bind and activate opioid receptors in the fetal brain, which could lead to long-term brain and behavioral disruptions. We hypothesized that maternal treatment with oxycodone (OXY), the
Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation.
Jonathan R McDaniel et al.
Angewandte Chemie (International ed. in English), 52(6), 1683-1687 (2013-01-03)
M Kokki et al.
British journal of anaesthesia, 112(1), 133-140 (2013-10-18)
Despite being increasingly used for pain management, only two studies, with controversial results, have evaluated the epidural use of oxycodone. Twenty-four women, aged 26-64 yr, undergoing elective gynaecological surgery were enrolled in this randomized, double-blinded, parallel group study. The subjects
Marco Pravetoni et al.
Journal of medicinal chemistry, 56(3), 915-923 (2012-12-20)
Prescription opioids abuse and associated deaths are an emerging concern in the USA. Vaccination against prescription opioids may provide an alternative to pharmacotherapy. An oxycodone hapten containing a tetraglycine linker at the C6 position (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin
Brady K Atwood et al.
Nature neuroscience, 17(4), 540-548 (2014-02-25)
As prescription opioid analgesic abuse rates rise, so does the need to understand the long-term effects of opioid exposure on brain function. The dorsal striatum is an important site for drug-induced neuronal plasticity. We found that exogenously applied and endogenously
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