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Merck
CN
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安全信息

O0200000

乌本苷

European Pharmacopoeia (EP) Reference Standard

别名:

乌本苷 八水合物, 1β,3β,5β,11α,14,19-Hexahydroxycard-20（22）-烯醇内酯-3-（6-脱氧-α-L-甘露糖苷）, G-毒毛花苷, 乌本苷

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About This Item

经验公式（希尔记法）:
C29H44O12 · 8H2O
CAS号:
11018-89-6
分子量:
728.77
Beilstein:
101712
MDL编号:
MFCD00149240
UNSPSC代码:
41116107
PubChem化学物质编号:
329818827
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

ouabain

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

O.O.O.O.O.O.O.O.C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O

InChI

1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-;;;;;;;;/m0......../s1

InChI key

TYBARJRCFHUHSN-DMJRSANLSA-N

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一般描述

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。

应用

哇巴因EP参考标准品的预期用途是欧洲药典规定的实验室测试。

包装

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

其他说明

可能适用相应的销售限制。

相关产品

产品编号
说明
价格

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300,H331,H373

危险分类

Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

法规信息

危险化学品

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Li Meng et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 1841-1848 (2016-11-30)
The steroid Na+/K+-ATPase blocker ouabain has been shown to exhibit cytotoxic effects in various tumor cell systems. This study aimed to determine the effects of ouabain on Burkitt's lymphoma Raji cells. Ouabain treatment of Raji cells significantly inhibited cell proliferation
Meneka Kanagaratnam et al.
The Journal of physiology, 595(11), 3471-3482 (2017-02-19)
Optic nerve axons get less excitable with warming. F-fibre latency does not shorten at temperatures above 30°C. Action potential amplitude falls when the Na Raising the temperature of optic nerve from room temperature to near physiological has effects on the
Sarunporn Tandhavanant et al.
mBio, 9(4) (2018-07-26)
Many Gram-negative bacterial symbionts and pathogens employ a type III secretion system (T3SS) to live in contact with eukaryotic cells. Because T3SSs inject bacterial proteins (effectors) directly into host cells, the switching of secretory substrates between translocators and effectors in
Qin Gong et al.
Nature communications, 9(1), 4993-4993 (2018-11-28)
Signals arising from bacterial infections are detected by pathogen recognition receptors (PRRs) and are transduced by specialized adapter proteins in mammalian cells. The Receptor-interacting-serine/threonine-protein kinase 2 (RIPK2 or RIP2) is such an adapter protein that is critical for signal propagation
Alexander Zhyvoloup et al.
PLoS pathogens, 13(7), e1006460-e1006460 (2017-07-21)
HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits wild-type HIV-1 infection more potently than HIV-1 bearing
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