推荐产品
等级
pharmaceutical primary standard
API类
olsalazine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
[Na+].[Na+].N(\N=C2/C=C(C(=O)C=C/2)C(=O)[O-])c1cc(c(cc1)O)C(=O)[O-]
InChI
1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,15,17H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-8-;;
InChI key
QQWFSVYVHLECFP-XBPUGJBTSA-L
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相关类别
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Olsalazine sodium for performance test EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kersti Oselin et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(9), 1452-1454 (2007-06-08)
Thiopurine S-methyltransferase (TPMT) is a biotransformation phase II enzyme responsible for the metabolic inactivation of thiopurine drugs. The present study was carried out to investigate the inhibitory potential of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) on human TPMT activity in vitro.
Xinming Li et al.
Journal of the American Chemical Society, 132(50), 17707-17709 (2010-12-03)
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the
K W Schroeder
Scandinavian journal of gastroenterology. Supplement, (236)(236), 42-47 (2002-11-01)
Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis in the early 1940s and later found effective in placebo-controlled trials for acute disease and for long-term maintenance of remission.
Yue-Meng Wan et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 22(5), 486-493 (2012-01-12)
We aimed to investigate the therapeutic effects of Peifeikang, a probiotics compound, on colitis in rats induced by trinitrobenzene sulfonic acid and to elucidate its potential mechanism. We evaluated the therapeutic effects of Peifeikang by analysis of the disease activity
Lutz Buschhausen et al.
Medizinische Klinik (Munich, Germany : 1983), 101(10), 791-795 (2006-10-14)
Patients with ulcerative colitis have a higher rate of tubular nephropathies. Data concerning the cause of these lesions is rare and inconsistent, the occurrence may be part of the disease itself or a side effect of 5-aminosalicylates (5-ASA). This study
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