所有图片(1)
别名:
5-溴烟酸 10-甲氧基-1,6-二甲基麦角灵-8-甲酯
经验公式（希尔记法）:
C24H26BrN3O3
CAS号:
分子量:
484.39
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级
analytical standard
质量水平
检测方案
≥97% (TLC)
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
格式
neat
储存温度
2-8°C
SMILES字符串
[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC
InChI
1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChI key
YSEXMKHXIOCEJA-FVFQAYNVSA-N
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一般描述
Nicergoline is an ergot derivative, which may be used in the treatment of affective, cognitive and behavioral disorders seen in older people. It is an α -adrenergic antagonist that may be used for companion animals like cats and dogs to treat, behavioral disorders, problems with aging, excessive vocaliztion and restessness.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
大脑和周边血管舒张剂
Maddison.EJ, et al.
Small Animal Clinical Pharmacology (2008)
Nicergoline for dementia and other age associated forms of cognitive impairment
MF and LF
Cochrane database of systematic reviews (Online), 2001-2001 null
Filippo Caraci et al.
Brain research, 1047(1), 30-37 (2005-05-11)
Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against beta-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of beta-amyloid
Jun-Sub Choi et al.
The ocular surface, 11(1), 16-18 (2013-01-17)
Many factors are involved in the corneal wound healing mechanism, including adhesion, migration, and proliferation of corneal epithelial cells. Abnormal corneal wound healing leads to corneal edema, neovascularization, scar formation, and poor vision. Three agents, 17β-estradiol, nicergoline, and β-glucan, have
Ledjan Malaj et al.
Journal of pharmaceutical sciences, 100(7), 2610-2622 (2011-01-22)
Nicergoline (NIC), a poorly water-soluble semisynthetic ergot derivative, was crystallized from several organic solvents, obtaining two different polymorphic forms, the triclinic form I and the orthorhombic form II. NIC samples were then characterized by several techniques such as (13)C cross-polarization
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