生物来源
synthetic (organic)
质量水平
Agency
USP/NF
meets USP testing specifications
检测方案
99.0-101.0% dry basis
形式
powder
颜色
white
mp
236-239 °C (lit.)
应用
pharmaceutical (small molecule)
SMILES字符串
OC(=O)c1cccnc1
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
基因信息
human ... CYP1A2(1544)
rat ... Chrnb2(54239)
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一般描述
Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.
应用
Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.
生化/生理作用
Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow
Kostecki LM
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 625(1-2), 50-61 (2007)
Effect of pO2 on antitumor drug cytotoxicity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line
Lelong-Rebel I, et al.
Anticancer Research, 28(1A), 55-68 (2008)
Nicotinic acid: a lipid-lowering agent with unrealized potential
Aboulsoud SH
The Egyptian Journal of Internal Medicine, 26(1), 1-1 (2014)
Pellagra: a non-eradicated old disease
Savvidou S
Clinics and practice, 4(1) (2014)
Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
D Andrea E, et al.
JAMA network open, 2(4), e192224-e192224 (2019)
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