N2144
7-氯-5-(2-氟苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮
analytical standard
别名:
脱烃基氟胺安定
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关于此项目
经验公式（希尔记法）:
C15H10ClFN2O
化学文摘社编号:
分子量:
288.70
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
220-748-3
MDL number:
InChI key
UVCOILFBWYKHHB-UHFFFAOYSA-N
InChI
1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
SMILES string
Fc1ccccc1C2=NCC(=O)Nc3ccc(Cl)cc23
grade
analytical standard
assay
≥98%
drug control
USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); regulated under CDSA - not available from Sigma-Aldrich Canada
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
氟胺安定的主要人体代谢物
signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Katharina Koch et al.
Drug testing and analysis (2018-04-11)
Novel synthetic opioids and benzodiazepines are an emerging trend on the narcotic drugs market. We present a lethal case of U-47700 and flubromazepam poisoning. A 24-year-old man suffered apnoea after the consumption of the synthetic opioid U-47700 in combination with
S Dunlop et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1064, 22-27 (2017-09-11)
The objective of this work was to establish an analytical method for the analysis of 7 Benzodiazepines (diazepam, oxazepam, temazepam, nordiazepam, desalkylflurazepam, alprazolam and α-hydroxyalprazolam) in urine specimens taken from drivers suspected of driving under the influence of drugs. The
N Zampaglione et al.
Drug metabolism and disposition: the biological fate of chemicals, 13(1), 25-29 (1985-01-01)
The absorption, metabolism, and excretion of quazepam, a new benzodiazepine hypnotic, was investigated in six normal male volunteers after oral administration of 25 mg 14C-quazepam in solution. Quazepam was well absorbed. Plasma radioactivity peaked (324.6 ng quazepam eq/ml) 1.75 hr
Kimiyasu Kato et al.
Therapeutic drug monitoring, 25(4), 473-477 (2003-07-29)
The effects of itraconazole, a potent inhibitor of cytochrome P450 (CYP) 3A4, on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug were studied. Ten healthy male volunteers received itraconazole 100
J M Hilbert et al.
Clinical pharmacology and therapeutics, 36(1), 99-104 (1984-07-01)
The effect of sleep on quazepam kinetics was studied in 12 normal adult men. In a randomized two-way crossover design, each subject received one 15-mg quazepam tablet either at night just before sleep or in the morning after a night's
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