InChI
1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;
SMILES string
Cl.CNCC\C=C1/c2ccccc2COc3ccccc13
InChI key
GNPPEZGJRSOKRE-QFHYWFJHSA-N
grade
analytical standard
assay
≥98.0% (TLC)
form
powder
technique(s)
HPLC: suitable
color
white to yellow
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Application
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Biochem/physiol Actions
多塞平代谢物。
Features and Benefits
粉末的保质期至少为10年。
Other Notes
顺式和反式异构体的混合物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
Antonia Gronewold et al.
Forensic science international, 190(1-3), 74-79 (2009-06-16)
Body fluids and tissues in eight doxepin (Dox)-related deaths were investigated in order to prove whether the individual concentration of Dox, the concentration sum of parent drug and its active metabolite N-desmethyldoxepin (NDox) or the concentration ratio Dox/Ndox valuably contribute
Anna Koski et al.
The American journal of forensic medicine and pathology, 28(3), 259-261 (2007-08-28)
It has been suggested that the polymorphism of the CYP2D6 gene can contribute to occurrence of fatal adverse effects. We therefore investigated postmortem toxicology cases of fatal drug poisonings related to CYP2D6 substrates, with the manner of death denoted as
M Adamczyk et al.
Therapeutic drug monitoring, 17(4), 371-376 (1995-08-01)
A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin. A 3-microns analytical silica column (6 x 100 mm) was employed with the mobile phase
Sebastian Härtter et al.
Pharmaceutical research, 19(7), 1034-1037 (2002-08-16)
This study was conducted to identify the cytochrome P450s (CYPs) responsible for the metabolism of the cis- and trans-isomers of the tricyclic antidepressant doxepin to its pharmacologically active N-desmethylmetabolite by in vitro techniques. The doxepin N-demethylation was studied by means
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