等级
analytical standard
质量水平
检测方案
≥98.0% (TLC)
形式
powder
技术
HPLC: suitable
颜色
white to yellow
应用
forensics and toxicology
pharmaceutical (small molecule)
格式
neat
SMILES字符串
Cl.CNCC\C=C1/c2ccccc2COc3ccccc13
InChI
1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;
InChI key
GNPPEZGJRSOKRE-QFHYWFJHSA-N
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应用
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生化/生理作用
多塞平代谢物。
特点和优势
粉末的保质期至少为10年。
其他说明
顺式和反式异构体的混合物
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
Antonia Gronewold et al.
Forensic science international, 190(1-3), 74-79 (2009-06-16)
Body fluids and tissues in eight doxepin (Dox)-related deaths were investigated in order to prove whether the individual concentration of Dox, the concentration sum of parent drug and its active metabolite N-desmethyldoxepin (NDox) or the concentration ratio Dox/Ndox valuably contribute
Anna Koski et al.
The American journal of forensic medicine and pathology, 28(3), 259-261 (2007-08-28)
It has been suggested that the polymorphism of the CYP2D6 gene can contribute to occurrence of fatal adverse effects. We therefore investigated postmortem toxicology cases of fatal drug poisonings related to CYP2D6 substrates, with the manner of death denoted as
J Yan et al.
Journal of chromatography. B, Biomedical sciences and applications, 691(1), 131-138 (1997-03-28)
Doxepin is a tricyclic antidepressant marketed as an irrational mixture of cis- and trans-geometric isomers in the ratio of 15:85. A convenient high-performance liquid chromatographic (HPLC) procedure for simultaneous quantitation of geometric isomers of doxepin and N-desmethyldoxepin in plasma and
M Adamczyk et al.
Therapeutic drug monitoring, 17(4), 371-376 (1995-08-01)
A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin. A 3-microns analytical silica column (6 x 100 mm) was employed with the mobile phase
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