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Merck
CN

M3761

Supelco

甲硝唑

analytical standard

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别名:
2-甲基-5-硝基咪唑-1-乙醇
经验公式(希尔记法):
C6H9N3O3
CAS号:
分子量:
171.15
Beilstein:
611683
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

形式

crystalline

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

159-161 °C (lit.)

抗生素抗菌谱

Gram-negative bacteria
parasites

应用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES字符串

CC1=NC=C([N+]([O-])=O)N1CCO

InChI

1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

InChI key

VAOCPAMSLUNLGC-UHFFFAOYSA-N

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一般描述

甲硝唑(Metronidazole)是一种硝基咪唑类药物,尤其适合用于治疗由厌氧菌和原生动物引起的人类和家畜感染。

应用

此分析标准品可用于以下用途:
  • 碳糊电极 (CPE) 循环伏安法测定三种不同品牌甲硝唑片中甲硝唑的含量
  • 采用反相高效液相色谱-光电二极管阵列检测器(RP- HPLC-DAD)同时测定制药剂量的甲硝唑、二氯尼特、螺旋霉素和克利喹诺
  • 开发基于聚多巴胺/羧基多壁碳纳米管(MWCNTs-COOH)纳米复合材料的电化学传感器,测定甲硝唑
  • 液相色谱–离子阱质谱法(LC-MS/MS法分析在水、沉积物和鱼组织样本中的甲硝唑)
  • 基于多壁碳纳米管 (MWCNT) 和壳聚糖-镍络合物 (CTS-Ni) 的电化学传感器测定片剂、人尿液和血清样品中的甲硝唑

其他说明

有关合适的仪器技术的更多信息,请参阅产品′的检验报告。想要获得更多支持,请联系技术服务部。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Carc. 1B - Muta. 1B - STOT RE 2

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Alison L Huckenpahler et al.
Translational vision science & technology, 9(10), 18-18 (2020-09-29)
To observe and characterize cone degeneration and regeneration in a selective metronidazole-mediated ablation model of ultraviolet-sensitive (UV) cones in zebrafish using in vivo optical coherence tomography (OCT) imaging. Twenty-six sws1:nfsB-mCherry;sws2:eGFP zebrafish were imaged with OCT, treated with metronidazole to selectively
Samrah Masud et al.
Autophagy, 15(5), 796-812 (2019-01-25)
Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little is known of the role that
Marcos Sande-Melón et al.
Cell reports, 29(4), 1041-1054 (2019-10-24)
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10
Christina M Surawicz et al.
The American journal of gastroenterology, 108(4), 478-498 (2013-02-27)
Clostridium difficile infection (CDI) is a leading cause of hospital-associated gastrointestinal illness and places a high burden on our health-care system. Patients with CDI typically have extended lengths-of-stay in hospitals, and CDI is a frequent cause of large hospital outbreaks
T H I Brummer et al.
BJOG : an international journal of obstetrics and gynaecology, 120(10), 1269-1276 (2013-06-22)
To evaluate cefuroxime and metronidazole antibiotic prophylaxis. Observational nonrandomised 1-year prospective cohort study. Fifty-three hospitals in Finland. A total of 5279 women undergoing hysterectomy for benign indications, with cefuroxime given to 4301 and metronidazole given to 2855. Excluding other antibiotics

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