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Merck
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主要文件

M1880000

咪康唑

European Pharmacopoeia (EP) Reference Standard

别名:

(±)-1-[2-(2,4-二氯苄氧基)-2-(2,4-二氯苯基)乙基]-1H-咪唑

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About This Item

经验公式(希尔记法):
C18H14Cl4N2O
CAS号:
分子量:
416.13
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

miconazole

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

Clc1c(ccc(c1)Cl)C(OCc3c(cc(cc3)Cl)Cl)C[n]2cncc2

InChI

1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2

InChI key

BYBLEWFAAKGYCD-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Miconazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 4

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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D A Stevens et al.
The American journal of medicine, 60(2), 191-202 (1976-02-01)
Fourteen patients with chronic coccidioidomycosis, many of whom had complicating concurrent diseases and/or had failed to respond to amphotericin therapy, were treated with intravenous miconazole, a synthetic imidazole drug previously shown to be effective in experimental murine coccidioidomycosis. Up to
R C Heel et al.
Drugs, 19(1), 7-30 (1980-01-01)
Miconazole is an imidazole antifungal drug which has recently become available for systemic use. Its antifungal activity has been well studied and it is active in vitro against a wide range of fungi. Published and unpublished reports of the use
Pascale Quatresooz et al.
Expert opinion on pharmacotherapy, 9(11), 1927-1934 (2008-07-17)
Miconazole nitrate is a time-honored antifungal of the imidazole class. To revisit the various aspects of action of the drug in a dermatologic setting. Review of the current peer-reviewed publications. Miconazole essentially inhibits 14alpha-demethylase, an enzyme required for the biosynthesis
J Symoens
Proceedings of the Royal Society of Medicine, 70 Suppl 1, 4-8 (1977-01-01)
Intravenous treatment with miconazole brought about the recovery of 90% of patients with gastrointestinal or systemic candidosis. Miconazole given by the same route has also been found effective in the treatment of cryptococcosis, coccidioidomycosis, and paracoccidioidomycosis. Cryptococcal and coccidioidal meningitis
A Miki et al.
Journal of clinical pharmacy and therapeutics, 36(6), 642-650 (2010-12-15)
Miconazole is a strong inhibitor of CYP2C9, one of the main enzymes involved in the metabolism of warfarin. Concurrent use of the two drugs leads to potentially serious adverse effects. Although it is often assumed that use of the oral

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