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Merck
CN

M0605000

二甲双胍 盐酸盐

European Pharmacopoeia (EP) Reference Standard

别名:

1,1-二甲双胍 盐酸盐, 盐酸二甲双胍

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About This Item

线性分子式:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
CAS号:
分子量:
165.62
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

Agency

EP Reference standard

API类

metformin

制造商/商品名称

EDQM

mp

223-226 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

Cl[H].CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

基因信息

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一般描述

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持,请访问现行药典网站。

应用

盐酸二甲双胍EP 参考标准品设计用于欧洲药典规定的实验室测试。

生化/生理作用

二甲双胍是一种降糖药,可以降低血糖水平,提高胰岛素敏感性。 它的代谢作用,包括抑制肝脏糖异生,至少部分是通过激活LKB1-AMPK(AMP活化蛋白激酶)通路介导的。 这一通路的激活也参与了二甲双胍在癌细胞系中的抗增殖和促凋亡作用。

包装

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

其他说明

可能会销售限制。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 808(2), 215-219 (2004-07-21)
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T W Hale et al.
Diabetologia, 45(11), 1509-1514 (2002-11-19)
The aim of this study was to characterize the milk-to-plasma ratio and infant dose for metformin in breastfeeding women, and to measure plasma concentrations and assess any effects in their infants. We hypothesized that metformin used by mothers is safe
J Radziuk et al.
Diabetes/metabolism research and reviews, 17(4), 250-272 (2001-09-07)
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