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等级
pharmaceutical primary standard
API类
lomustine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
ClCCN(N=O)C(=O)NC1CCCCC1
InChI
1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChI key
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Lomustine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
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产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Carc. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.
L M Fulton et al.
Seminars in veterinary medicine and surgery (small animal), 5(4), 241-245 (1990-11-01)
G A Kaltsas et al.
Clinical endocrinology, 57(2), 169-183 (2002-08-03)
Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.
S J Proctor et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 21(2), 426-428 (2009-11-11)
The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).
R B Weiss et al.
Cancer treatment reviews, 9(4), 313-330 (1982-12-01)
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