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Merck
CN

I3261

Indo 1-AM

93 - 100% purity

别名:

4-(6-Carboxy-2-indolyl)-4′-methyl-2,2′-(ethylenedioxy)dianiline-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl) ester

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关于此项目

经验公式（希尔记法）:
C47H51N3O22
化学文摘社编号:
112926-02-0
分子量:
1009.91
PubChem Substance ID:
24896026
UNSPSC Code:
12171500
MDL number:
MFCD00036955

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产品名称

Indo 1-AM, ~95% (HPLC)

InChI

1S/C47H51N3O22/c1-28-7-11-39(49(19-43(56)68-23-63-29(2)51)20-44(57)69-24-64-30(3)52)41(15-28)61-13-14-62-42-18-35(37-16-34-8-9-36(17-38(34)48-37)47(60)72-27-67-33(6)55)10-12-40(42)50(21-45(58)70-25-65-31(4)53)22-46(59)71-26-66-32(5)54/h7-12,15-18,48H,13-14,19-27H2,1-6H3

SMILES string

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc2cc(ccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c3cc4ccc(cc4[nH]3)C(=O)OCOC(C)=O

InChI key

CAWBRCOBJNWRLK-UHFFFAOYSA-N

assay

~95% (HPLC)

fluorescence

λex 330 nm; λem 450 nm (with Calcium), λex 356 nm; λem 478 nm in methanol

storage temp.

−20°C

Quality Level

100

Application

细胞可渗透性Ca2+荧光探针；亲和力低于FURA 2；使荧光发射在Ca2+结合后从482 nm大幅转变为398 nm。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKBW8742V
MKCF1669
MKCC4756
MKCC1633
MKBZ4230V

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CD2 sets quantitative thresholds in T cell activation.
Bachmann MF
The Journal of Experimental Medicine, 190, 1383-1383 (1999)
Simultaneous recording of calcium transients and reactive oxygen intermediates of human polymorphonuclear granulocytes in response to formyl-Met-Leu-Phe and the environmental agent sulfite.
Grundler W
Cytometry, 40, 219-219 (2000)
E Roux et al.
American journal of respiratory cell and molecular biology, 19(3), 437-444 (1998-09-09)
We have previously observed that acrolein administered ex vivo to isolated airways alters the subsequent airway responsiveness. To examine the cellular mechanisms involved in this alteration, we have studied the effect of acrolein exposure on calcium signaling in myocytes freshly
Y-J Chen et al.
British journal of pharmacology, 153(5), 915-925 (2007-11-13)
Pulmonary veins are the most important focus for the generation of atrial fibrillation. Abnormal calcium homeostasis with ryanodine receptor dysfunction may underlie the arrhythmogenic activity in pulmonary veins. The preferential ryanodine receptor stabilizer (K201) possesses antiarrhythmic effects through calcium regulation.
M C Catlin et al.
Cytometry, 41(2), 123-132 (2000-09-26)
The objective of this study was to characterize and quantitate the calcium responses to cholinergic stimulation in individual primary rat cortical astrocytes and human 132 1N1 astrocytoma cells. Materials and Methods The fluorescent calcium probe Indo-1 AM and an attached
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