I114
对碘可乐定 盐酸盐
analytical standard, for drug analysis
别名:
2-[(2,6-二氯-4-碘苯基)亚氨基]咪唑啉 盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C9H8Cl2IN3 · HCl
化学文摘社编号:
分子量:
392.45
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
对碘可乐定 盐酸盐, analytical standard, for drug analysis
InChI
1S/C9H8Cl2IN3.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2H2,(H2,13,14,15);1H
SMILES string
Cl[H].Clc1cc(I)cc(Cl)c1\N=C2/NCCN2
InChI key
ULCGXOSKNHMYAX-UHFFFAOYSA-N
form
solid
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
color
white to off-white
solubility
H2O: soluble
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Biochem/physiol Actions
高亲和性 α2 肾上腺素受体激动剂。
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
H Zhu et al.
Life sciences, 61(19), 1973-1983 (1997-01-01)
One subtype of imidazoline receptors (IR1) is similar to alpha 2-adrenoceptors (alpha 2 AR) based on their high affinity for clonidine and related imidazoline compounds. On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines. Imidazoline
Jan Höcker et al.
The Journal of pharmacy and pharmacology, 61(7), 901-910 (2009-07-11)
alpha(2)-Adrenergic and mu-opioid receptors belong to the rhodopsin family of G-protein coupled receptors and mediate antinociceptive effects via similar signal transduction pathways. Previous studies have revealed direct functional interactions between both receptor systems including synergistic and additive effects. To evaluate
F M Heemskerk et al.
Journal of neurochemistry, 71(5), 2193-2202 (1998-11-03)
Nonadrenergic imidazoline-specific binding sites were characterized pharmacologically in crude cerebral membrane preparations, but little is known about their subcellular localization in neurons. As in the brainstem these sites are involved in cardiovascular regulation and peripherally imidazolines modulate neurotransmitter release, we
J E Piletz et al.
Journal of psychiatric research, 32(2), 55-64 (1998-08-07)
A comparison is presented between plasma catecholamine concentrations and platelet [125I]-p-iodoclonidine binding sites in 16 healthy women. Blood samples were obtained at six regularly spaced intervals over two consecutive menstrual cycles from healthy women with regular menstrual periods. Although no
N Benedetto et al.
Pathologie-biologie, 45(1), 9-18 (1997-01-01)
We investigated the effects of alpha-adrenergic on the capacity of Toxoplasma gondii to invade and proliferate in cultured human umbilical vein endothelial cells. Pretreatment of human umbilical vein endothelial cells (HUVEC) with alpha 2-adrenergic led to a high degree of
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