I114
对碘可乐定 盐酸盐
analytical standard, for drug analysis
别名:
2-[(2,6-二氯-4-碘苯基)亚氨基]咪唑啉 盐酸盐
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关于此项目
经验公式（希尔记法）:
C9H8Cl2IN3 · HCl
化学文摘社编号:
分子量:
392.45
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C9H8Cl2IN3.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2H2,(H2,13,14,15);1H
SMILES string
Cl[H].Clc1cc(I)cc(Cl)c1\N=C2/NCCN2
InChI key
ULCGXOSKNHMYAX-UHFFFAOYSA-N
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white to off-white
solubility
H2O: soluble
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
高亲和性 α2 肾上腺素受体激动剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jan Höcker et al.
The Journal of pharmacy and pharmacology, 61(7), 901-910 (2009-07-11)
alpha(2)-Adrenergic and mu-opioid receptors belong to the rhodopsin family of G-protein coupled receptors and mediate antinociceptive effects via similar signal transduction pathways. Previous studies have revealed direct functional interactions between both receptor systems including synergistic and additive effects. To evaluate
H Zhu et al.
Life sciences, 61(19), 1973-1983 (1997-01-01)
One subtype of imidazoline receptors (IR1) is similar to alpha 2-adrenoceptors (alpha 2 AR) based on their high affinity for clonidine and related imidazoline compounds. On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines. Imidazoline
J E Piletz et al.
The Journal of pharmacology and experimental therapeutics, 267(3), 1493-1502 (1993-12-01)
Human platelets are shown to possess at least two high-affinity, imidazol(in)e-preferring binding sites that are pharmacologically distinct from alpha-2 adrenoceptors. These nonadrenergic sites were radiolabeled even in the presence of a 10 microM norepinephrine mask of alpha-2 adrenoceptors. Heterogeneity at
P Ernsberger et al.
The Journal of pharmacology and experimental therapeutics, 264(1), 172-182 (1993-01-01)
Both the hypotension and the sedation elicited by centrally acting antihypertensive agents are traditionally attributed to activation of alpha 2 adrenergic receptors. Second-generation centrally acting agents such as moxonidine are less sedating but retain antihypertensive efficacy. A novel receptor which
M A Gerhardt et al.
Molecular pharmacology, 38(2), 214-221 (1990-08-01)
The binding properties of p-[125I]iodoclonidine [( 125I]PIC) to human platelet membranes and the functional characteristics of PIC are reported. [125I]PIC bound rapidly and reversibly to platelet membranes, with a first-order association rate constant (kon) at room temperature of 8.0 +/-
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