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安全和法规

H1400000

醋酸氢化可的松

Name: 醋酸氢化可的松
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

醋酸氢化可的松, 11β,17α,21-三羟基-4-孕烯-3,20-二酮 21-乙酸酯, 17-α-羟基皮质甾酮乙酸酯, 17-羟基皮质甾酮 21-乙酸酯, 21-乙酰氧基-4-孕烯-11β,17α-二醇-3,20-二酮, 4-孕烯-11β,17α,21-三醇-3,20-二酮 21-乙酸酯

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About This Item

经验公式（希尔记法）:

C₂₃H₃₂O₆

CAS号:

50-03-3

分子量:

404.50

Beilstein:

2066841

MDL编号:

MFCD00037714

UNSPSC代码:

41116107

PubChem化学物质编号:

329815160

NACRES:

NA.24

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Supelco

PHR1606

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USP

1317007

醋酸氢化可的松

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BP584

醋酸氢化可的松

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Sigma-Aldrich

H4126

醋酸氢化可的松

H1300000

氢化可的松

等级

pharmaceutical primary standard

API类

hydrocortisone

制造商/商品名称

EDQM

mp

223 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

基因信息

human ... NR3C1(2908)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Hydrocortisone acetate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

警示用语：

Danger

危险声明

H360Df,H373

预防措施声明

P202 - P260 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

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Novel nanoparticulate gel formulations of steroids for the treatment of macular edema.

Sai H S Boddu et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 26(1), 37-48 (2010-02-13)

This article describes the development and characterization of PLGA nanoparticles of dexamethasone (DEX), hydrocortisone acetate (HA), and prednisolone acetate (PA) suspended in thermosensitive gels indicated for the treatment of macular edema (ME). Nanoparticles were prepared by oil-in-water (O/W) emulsion and

One-year treatment with 0.1% tacrolimus ointment versus a corticosteroid regimen in adults with moderate to severe atopic dermatitis: A randomized, double-blind, comparative trial.

Johanna Mandelin et al.

Acta dermato-venereologica, 90(2), 170-174 (2010-02-20)

A one-year, randomized, double-blind study was conducted in 80 patients with atopic dermatitis treated with tacrolimus ointment or a corticosteroid regimen (hydrocortisone acetate 1% ointment for head and neck, hydrocortisone butyrate 0.1% ointment for trunk and limbs) to compare efficacy

Neuroendocrine disorders in adult rats treated prenatally with hydrocortisone acetate.

Alexander Reznikov et al.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 60(6), 489-497 (2008-08-12)

We investigated the effects of hydrocortisone acetate administered to pregnant rats over the last gestational week on some neuroendocrine characteristics in adult female and male offspring. Prenatal glucocorticoid eliminated sex dimorphism of the neurons nuclei volumes in the medial preoptic

Injectable PLGA/hydrocortisone formulation produced by continuous supercritical emulsion extraction.

Nunzia Falco et al.

International journal of pharmaceutics, 441(1-2), 589-597 (2012-11-06)

The objective of the present study was to develop an anti-inflammatory prolonged action formulation for local injection in prefilled syringes. Hydrocortisone acetate (HA) was selected as a model corticosteroid drug to be incorporated in poly(lactic-co-glycolic) (PLGA) microspheres. The formulation was

Optimization and validation of an RP-HPLC method for analysis of hydrocortisone acetate and lidocaine in suppositories.

Biljana Jancic-Stojanović et al.

Journal of AOAC International, 93(1), 102-107 (2010-03-26)

An RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance. The

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醋酸氢化可的松

European Pharmacopoeia (EP) Reference Standard

About This Item

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等级

API类

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mp

应用

包装形式

SMILES字符串

InChI

InChI key

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其他说明

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WGK

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闪点(°C)

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