推荐产品
质量水平
类型
Grade I
表单
liquid
浓度
25% in H2O
技术
electron microscopy: suitable (fixative)
electron microscopy: suitable
颜色
colorless
有效pH范围
2.9
mp
-10 °C ((14 °F ))
溶解性
water: soluble at 20 °C
应用
cell analysis
运输
dry ice
储存温度
−20°C
SMILES字符串
[H]C(CCCC([H])=O)=O
InChI
1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
InChI key
SXRSQZLOMIGNAQ-UHFFFAOYSA-N
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相关类别
一般描述
戊二醛（1,5-戊二醛）是一种脂肪族二醛，常用作多功能生物化学试剂。戊二醛溶液由固定性能不同的单体和聚合体混合而成。其应用包括作为蛋白质交联剂，促进显微镜学、组织化学和细胞化学中酶的固定。该化合物可用作SDS-PAGE、染色或电子显微镜检查之前的胺反应性同型双功能交联剂和细胞固定剂，适用于各种形态学研究。
戊二醛可以使胺和肼衍生物与蛋白质和其它含胺聚合物高效交联。特别值得一提的是，它已被用于某些反应中，使生物素酰肼与核酸直接结合，其潜在应用为荧光酰肼和羟胺与DNA的偶联。在组织学研究中，戊二醛可用于保存组织切片，以便进行更密切的检查。
戊二醛可以使胺和肼衍生物与蛋白质和其它含胺聚合物高效交联。特别值得一提的是，它已被用于某些反应中，使生物素酰肼与核酸直接结合，其潜在应用为荧光酰肼和羟胺与DNA的偶联。在组织学研究中，戊二醛可用于保存组织切片，以便进行更密切的检查。
应用
戊二醛溶液已用于：
- 固定血液样品，进行扫描电镜(SEM)观察
- 固定支架进行SEM分析
- 在药物实验中处理K562（白血病）细胞，永久交联细胞组分
生化/生理作用
戊二醛在生物医学研究中可用来固定细胞。还可作为健康和病理红细胞的研究工具。戊二醛广泛用于消毒各种医疗器械，包括内窥镜、透析管、血液透析比例混合和透析液供给系统、腔内探头、换能器、麻醉、呼吸治疗设备以及一次性腹腔镜塑料套管的再利用。
特点和优势
- 功能强大，适用于各种研究应用
- 即用型溶液减少制备时间
其他说明
推荐用于需要高纯度的技术。
可比产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Malwina Sosnowska et al.
International journal of nanomedicine, 14, 6197-6215 (2019-09-10)
Degradation of the extracellular matrix (ECM) changes the physicochemical properties and dysregulates ECM-cell interactions, leading to several pathological conditions, such as invasive cancer. Carbon nanofilm, as a biocompatible and easy to functionalize material, could be used to mimic ECM structures
Jules D P Valentin et al.
Journal of colloid and interface science, 552, 247-257 (2019-05-28)
Many materials used in the medical settings such as catheters and contact lenses as well as most biological tissues are not purely elastic, but rather viscoelastic. While substrate elasticity has been investigated for its influence on bacterial adhesion, the impact
Mariafrancesca Cascione et al.
International journal of molecular sciences, 20(14) (2019-07-26)
The side effects induced by nanoparticle exposure at a cellular level are one of the priority research topics due to the steady increase in the use of nanoparticles (NPs). Recently, the focus on cellular morphology and mechanical behavior is gaining
Irene Costantini et al.
Scientific reports, 5, 9808-9808 (2015-05-08)
Extensive mapping of neuronal connections in the central nervous system requires high-throughput µm-scale imaging of large volumes. In recent years, different approaches have been developed to overcome the limitations due to tissue light scattering. These methods are generally developed to
Stéphane Jauréguiberry et al.
Blood, 124(2), 167-175 (2014-05-27)
Patients with severe malaria treated with artesunate sometimes experience a delayed hemolytic episode. Artesunate (AS) induces pitting, a splenic process whereby dead parasites are expelled from their host erythrocytes. These once-infected erythrocytes then return to the circulation. We analyzed hematologic
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