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Merck
CN

G4382

Supelco

(±)-骨化醇-乙酸

analytical standard, crystalline complex consisting of equimolar quantities of gossypol and acetic acid, ~95%

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About This Item

经验公式(希尔记法):
C30H30O8 · C2H4O2
CAS号:
分子量:
578.61
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

方案

~95% (HPLC)
~95%

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

food and beverages

包装形式

neat

储存温度

−20°C

SMILES字符串

CC(O)=O.CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O

InChI

1S/C30H30O8.C2H4O2/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36;1-2(3)4/h7-12,33-38H,1-6H3;1H3,(H,3,4)

InChI key

NIOHNDKHQHVLKA-UHFFFAOYSA-N

应用

有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务部门。

生化/生理作用

据报道可以抑制胃蛋白酶原向胃蛋白酶的自溶转化。

象形图

Health hazardExclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Asli Kisim et al.
Journal of cancer research and clinical oncology, 138(7), 1155-1163 (2012-03-14)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce extrinsic pathway of apoptosis in many types of cancer cells. AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that
Hope M Amm et al.
Molecular cancer research : MCR, 9(4), 403-417 (2011-03-02)
TRA-8, a monoclonal antibody to death receptor 5 induces apoptosis in various cancer cells; however, the degree of sensitivity varies from highly sensitive to resistant. We have previously shown that resistance to TRA-8 can be reversed by using chemotherapeutic agents
Simone Fulda
Planta medica, 76(11), 1075-1079 (2010-05-21)
Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple
Zhong Guo et al.
Sheng li xue bao : [Acta physiologica Sinica], 63(2), 164-170 (2011-04-21)
The present study was conducted to investigate the effects of gossypol acetic acid (GAA) on the proliferation of human mucoepidermoid carcinoma cell line MEC-1 in vitro and its possible molecular mechanisms of DNA double-strand breaks (DSB). MTT assay was performed
Natalie McGregor et al.
Journal of cellular biochemistry, 110(5), 1187-1194 (2010-07-01)
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common treatment for advanced prostate cancer patients; however, ADT fails in nearly all cases resulting in castration resistant or androgen-insensitive (AI)

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