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安全信息

G3632

Sigma-Aldrich

庆大霉素 硫酸盐

potency: ≥590 I.U. Gentamicin base per mg

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别名:
GM 硫酸盐, 庆大霉素 C
CAS号:
1405-41-0
EC 号:
215-778-9
MDL编号:
MFCD00270181
UNSPSC代码:
51281651
eCl@ss:
42020823
PubChem化学物质编号:
329799915
NACRES:
NA.76

生物来源

Micromonospora purpurea

质量水平

200

形式

powder

效能

≥590 I.U. Gentamicin base per mg
≥590 units/mg Gentamicin

储存条件

(Tightly closed. Dry. )

浓度

50 μg/mL in H2O (is the recommended working concentration for eukaryotic cell culture)

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

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相关类别

一般描述

硫酸庆大霉素盐是一种广谱氨基糖苷类抗生素，衍生自紫癜性小单孢子菌。

应用

硫酸庆大霉素在细胞培养和分子生物实验中作为选择剂（抗庆大霉素基因）。 产品推荐使用浓度是50mg/mL。 硫酸庆大霉素可用于：
  • 抗生素对不同细菌培养物的有效性研究中
  • 研究神经元信号处理

生化/生理作用

作用机制：庆大大霉素通过和30S核糖亚基结合，引起密码子误读，阻碍肽酰转移酶从供体位点转移到受体位点。庆大霉素通过它与外膜的结合来发挥它对铜绿假单胞菌的杀菌作用，它在外膜上置换天然阳离子，使膜不稳定，并在细胞表面形成孔。

抗菌谱：包括革兰氏阴性和革兰氏阳性细菌，包括对于四环素、氯霉素、卡那霉素和粘菌素，某些特定假单胞菌菌株，变形杆菌属，Staphylococcus 和 Streptococcus 的抗性。

特点和优势

适合多种研究应用的高质量抗生素

组分

庆大霉素是Micromonospora purpurea 或M. echinospora发酵后产生的氨基糖苷复合物。 它可以用来作为硫酸盐。 每摩尔庆大霉素基础有三个成分，每一个成分包含五份碱性氮，并且需要5份硫酸。
易溶于水，几乎不溶于乙醇

储存及稳定性

无菌溶液应储存在2-8°C条件下。溶液在室温及沸腾的pH 2-14的水性缓冲液中稳定。[2]

其他说明

For additional information on our range of Biochemicals, please complete this form.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

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Antimicrobial agents and chemotherapy, 38(11), 2577-2582 (1994-11-01)
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