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Merck
CN

F8798

Sigma-Aldrich

叶酸

meets USP testing specifications

别名:

N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸, PteGlu, 维生素 M

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About This Item

经验公式(希尔记法):
C19H19N7O6
CAS号:
分子量:
441.40
Beilstein:
100781
EC 号:
MDL编号:
UNSPSC代码:
12352100
eCl@ss:
34058014
PubChem化学物质编号:
NACRES:
NA.21

生物来源

synthetic (organic)

质量水平

Agency

USP/NF
meets USP testing specifications

检测方案

97.0-102.0% dry basis

形式

solid

颜色

yellow

mp

>285 °C

应用

cell analysis
pharmaceutical (small molecule)

SMILES字符串

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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一般描述

叶酸,也称为蝶酰-L-谷氨酸,属于维生素 B 群。已经基于核磁共振(NMR)和理论计算报道了溶液中叶酸的构象分析。已经研究了在紫外辐射下光分解的反应动力学。本产品是符合 USP(美国药典)测试规范的高质量药典产品。它可以用于研究和试点研究。

应用

叶酸已被用于研究中,以研究其对丙戊酸(VPA)对母体肝组织引起的毒性的保护作用。它也被用作反相 HPLC 定量血浆叶酸的标准。

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Solution structure of folic acid: Molecular mechanics and NMR investigation.
Bonechi C, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 60(7), 1411-1419 (2004)
Ultrastructural investigation of the protective role of folic acid and vitamin E against toxic effects of valproic acid on maternal liver tissue during period of gestation.
Ozlem P Baran et al.
Saudi medical journal, 27(3), 407-409 (2006-03-15)
Ultraviolet photodegradation of folic acid.
Off MK, et al.
Journal of Photochemistry and Photobiology. B, Biology, 80(1), 47-55 (2005)
Carolyn Tam et al.
Obstetrics and gynecology international, 2012, 485179-485179 (2012-04-25)
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age

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