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经验公式(希尔记法):
C20H10Na2O5
化学文摘社编号:
分子量:
376.27
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
208-253-0
MDL number:
Beilstein/REAXYS Number:
3833041
产品名称
荧光素 钠盐, used as fluorescent tracer
InChI
1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2
SMILES string
[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1
InChI key
RGPLGPBQJOQFJS-UHFFFAOYSA-L
form
powder
technique(s)
titration: suitable
pH
8.3 (20 °C, 10 g/L)
mp
>300 °C
solubility
H2O: 1 mg/mL
density
0.78 g/cm3 at 29.6 °C (85.3 °F at 699.7 hPa)
fluorescence
λex 460 nm; λem 515 nm(lit.)
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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General description
荧光素是一种黄嘌呤染料,是生物学中常用的标记试剂。
Application
水溶性荧光染料由于其分子半径小,渗透性和血管灌注研究中得到应用。 以荧光素钠作为荧光示踪剂,用于研究血脑屏障(BBB)和血脊髓屏障(BSCB)在啮齿类动物模型中的通透性。 以该染料为探针底物,研究了有机阴离子转运多肽(OATP)介导的肝细胞药物转运。荧光素钠还被应用于光致退色后 原位 溶质通过荧光恢复进入骨内。
荧光素钠盐被用作一种溶质,用于研究微血管渗透性。它已被用作研究血液屏障穿透性的测试分子。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
423.7 °F - Pensky-Martens closed cup
flash_point_c
217.6 °C - Pensky-Martens closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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American Journal of Physiology. Heart and Circulatory Physiology, 284, H2124-H2124 (2003)
The determination of the conduction mechanism and optical band gap of fluorescein sodium salt.
Yakuphanoglu F, et al.
Physica B: Condensed Matter, 382(1), 21-25 (2006)
Advanced Fluorescence Reporters in Chemistry and Biology I: Fundamentals and Molecular Design (2010)
Vascular endothelial growth factor enhances cancer cell adhesion to microvascular endothelium in vivo.
Shen S
Experimental Physiology, 95, 369-369 (2010)
Liyun Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(33), 11911-11916 (2005-08-10)
Solute transport through the bone lacunar-canalicular system is believed to be essential for osteocyte survival and function but has proved difficult to measure. We report an approach that permits direct measurement of real-time solute movement in intact bones. By using
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