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About This Item
经验公式（希尔记法）:
C8H10N2S
CAS号:
分子量:
166.24
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
ethionamide
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
CCc1cc(ccn1)C(N)=S
InChI
1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
InChI key
AEOCXXJPGCBFJA-UHFFFAOYSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Ethionamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
[ROLE OF ETHIONAMIDE IN THE DETERMINISM OF NEUROLOGIC COMPLICATIONS OCCURRING DURING ANTITUBERCULAR TREATMENTS].
G BROUET et al.
La Revue du praticien, 14, 289-307 (1964-01-21)
Tamao Nakashita et al.
Kekkaku : [Tuberculosis], 81(12), 731-735 (2007-01-24)
Cases of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with tuberculosis have been reported, however, in most of these cases, tuberculosis disease is miliary or severe. Here we report the first case of SIADH induced by ethionamide (TH).
Kerstin A Wolff et al.
Expert review of anti-infective therapy, 10(9), 971-981 (2012-10-31)
Antifolates inhibit de novo folate biosynthesis, whereas ethionamide targets the mycolate synthetic pathway in Mycobacterium tuberculosis. These antibiotics are effective against M. tuberculosis but their use has been hampered by concerns over toxicity and low therapeutic indexes. With the increasing
Ethionamide.
Tuberculosis (Edinburgh, Scotland), 88(2), 106-108 (2008-05-20)
Nuno Vale et al.
Current drug metabolism, 14(1), 151-158 (2012-12-12)
Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert
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